Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	122507
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Microbial succession driven by Alistipes depletion shapes the mesenchymal and immune-excluded consensus molecular subtype 4 colorectal cancer landscape
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Dong Hu, Chen-Jie Qiu, Zhen-Biao Song, Zi-Wei Xia, Hai-Tao Wang and Hui Geng
Funding Agency and Grant Number
Corresponding Author	Hai-Tao Wang, Professor, Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Soochow University, No. 185 Jiqian Street, Changzhou 213000, Jiangsu Province, China. 15961290078@163.com
Key Words	Colorectal cancer; Consensus molecular subtype 4; Microbial succession; Immune exclusion; Alistipes indistinctus; Fusobacterium
Core Tip	Consensus Molecular Subtype 4 colorectal cancer exhibits a unique microbial succession pattern. Depletion of Alistipes indistinctus initiates a cascade of pathogenic events, ultimately making Fusobacterium the dominant microbial taxon. This microbial shift may mediate tumor immune exclusion through extracellular matrix remodelling, indicating considerable potential for these microbial signatures to act as prognostic biomarkers and therapeutic targets for this refractory cancer subtype.
Citation	Hu JD, Qiu CJ, Song ZB, Xia ZW, Wang HT, Geng H. Microbial succession driven by Alistipes depletion shapes the mesenchymal and immune-excluded consensus molecular subtype 4 colorectal cancer landscape. World J Gastrointest Oncol 2026; In press

Received	2026-04-30 09:20
Peer-Review Started	2026-04-30 09:20
First Decision by Editorial Office Director	2026-05-22 03:04
Return for Revision	2026-05-22 03:04
Revised	2026-06-08 08:20
Publication Fee Transferred	2026-06-15 06:19
Second Decision by Editor	2026-06-25 02:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-25 03:54
Articles in Press	2026-06-25 03:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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