Publication Name	World Journal of Stem Cells
Manuscript ID	122513
DOI	10.4252/wjsc.122513
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Induced pluripotent stem cell-derived chimeric antigen receptor natural killer cells: Engineering innovations, translational hurdles and clinical prospects in immune therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Lin Liu, Si-Min Han, Gang-Hui Ye, Qing-Lu Wang, Ying Luo and Yan-Mei Liu
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Medical Health Science & Technology Project 2022KY1403 Natural Scientific Foundation of Shandong Province ZR2025MS1369
Corresponding Author	Ying Luo, MD, PhD, Department of Clinical Laboratory, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zhangdian District, Zibo 255000, Shandong Province, China. luoying1242@126.com
Key Words	Induced pluripotent stem cells; Chimeric antigen receptor natural killer cells; Off-the-shelf immunotherapy; Cell engineering; Clinical translation; Tumor microenvironment; Genome editing; Synthetic biology
Core Tip	Induced pluripotent stem cell-derived chimeric antigen receptor (CAR) natural killer cells provide a candidate standardized, cell-bank-driven platform for off-the-shelf immunotherapy. Their translational value should not be judged solely by CAR expression, enhanced cytotoxicity, or accumulated engineering modules. This review proposes a multilevel framework integrating product definition, effector execution, tissue delivery, host interaction, and translational implementation, and emphasizes dominant bottlenecks, evidence levels, engineering trade-offs, and the gap between preclinical functional enhancement and established clinical benefit.
Citation	Liu XL, Han SM, Ye GH, Wang QL, Luo Y, Liu YM. Induced pluripotent stem cell-derived chimeric antigen receptor natural killer cells: Engineering innovations, translational hurdles and clinical prospects in immune therapy. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.122513
PDF	122513-in-press.pdf

Received	2026-04-22 05:59
Peer-Review Started	2026-04-22 05:59
First Decision by Editorial Office Director
Return for Revision	2026-06-23 03:15
Revised	2026-06-30 17:47
Publication Fee Transferred
Second Decision by Editor	2026-08-03 02:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:17
Articles in Press	2026-08-28 09:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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