Publication Name	World Journal of Gastroenterology
Manuscript ID	122523
DOI	10.3748/wjg.122523
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Xin Zhang, Xin-Yi Fang, Yan-Jiao Zhang, Rui-Yang Yin, Bin Li and Jia-Xing Tian
Funding Agency and Grant Number	Funding Agency Grant Number GAMIMD Special Fund 2022LYJSZX12 CACMS Outstanding Young Scientific and Technological Talents Program ZZ13-YQ-026 CACM-PDP Dose-Effect Relationship Research Project 202428-002
Corresponding Author	Jia-Xing Tian, Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China. tina-yai@126.com
Key Words	Tangwei’an decoction; Diabetic gastroparesis; Multi-omics; COX6A2/SCF/c-Kit; Mitochondrial dynamics
Core Tip	Tangwei’an decoction (TWAD) is clinically used for diabetic gastroparesis (DGP), but its mechanism remains unclear. This study combined serum pharmacochemistry, integrated proteomics and metabolomics, and experimental validation to show that TWAD alleviates DGP by restoring mitochondrial dynamics. Oxidative phosphorylation was identified as the major pathway regulated by TWAD, with COX6A2 as a key target. TWAD also modulated the SCF/c-Kit axis, providing mechanistic support for its therapeutic potential in DGP.
Citation	Zhang YX, Fang XY, Zhang YJ, Yin RY, Li B, Tian JX. Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122523
PDF	122523-in-press.pdf

Received	2026-04-22 06:49
Peer-Review Started	2026-04-22 06:51
First Decision by Editorial Office Director	2026-05-27 06:23
Return for Revision	2026-05-27 06:23
Revised	2026-06-25 03:33
Publication Fee Transferred	2026-07-01 15:41
Second Decision by Editor	2026-07-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-13 09:24
Articles in Press	2026-07-13 09:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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