Publication Name	World Journal of Gastroenterology
Manuscript ID	122564
DOI	10.3748/wjg.122564
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Tirzepatide for refractory post-fundoplication dumping syndrome: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Olanrewaju Adeniran, Hamza Almusabeh, Ayowumi Adekolu, Kareem Diab, Jennifer Hadam, Nida S Bham and Zain A Sobani
Funding Agency and Grant Number
Corresponding Author	Zain A Sobani, Assistant Professor, Gastroenterology and Hepatology, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, United States. zsobani@gmail.com
Key Words	Dumping syndrome; Fundoplication; Tirzepatide; Glucagon-like peptide-1 agonist; Glucose-dependent insulinotropic peptide agonist; Gastric emptying; Case report
Core Tip	This report discusses a case of post-fundoplication dumping syndrome (DS), an underrecognized complication of para-esophageal herniorrhaphy, treated with tirzepatide. While an exaggerated incretin response can induce DS, glucagon-like peptide-1 (GLP-1) receptor and glucose-dependent insulinotropic peptide receptor agonists have demonstrated benefits in treating refractory cases. Our case underscores the importance of recognizing post-fundoplication DS and the potential of GLP-1-based therapies for refractory cases. Our patient’s symptoms recurrence during tapering, despite stable weight, highlights tirzepatide’s pharmacological potential in DS. This represents one of the first reported uses of tirzepatide post-fundoplication, resulting in DS resolution.
Citation	Adeniran O, Almusabeh H, Adekolu A, Diab K, Hadam J, Bham NS, Sobani ZA. Tirzepatide for refractory post-fundoplication dumping syndrome: A case report. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122564
PDF	122564-in-press.pdf

Received	2026-04-22 02:16
Peer-Review Started	2026-04-22 02:16
First Decision by Editorial Office Director	2026-05-26 08:45
Return for Revision	2026-05-26 08:45
Revised	2026-06-06 00:30
Publication Fee Transferred	2026-07-07 20:42
Second Decision by Editor	2026-08-05 03:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:34
Articles in Press	2026-08-05 10:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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