Publication Name	World Journal of Nephrology
Manuscript ID	122565
DOI	10.5527/wjn.122565
Country	India

Category	Biochemistry & Molecular Biology
Manuscript Type	Opinion Review
Article Title	SLC30A8 (ZnT8) at the crossroads of epigenetics and microRNA regulation in type 2 diabetes and nephropathy
Manuscript Source	Invited Manuscript
All Author List	Varun Kumar Sharma, Mirza Masroor Ali Beg, Shilpy Singh, Sourabh Kumar Singh and Dharmsheel Shrivastav
Funding Agency and Grant Number
Corresponding Author	Dharmsheel Shrivastav, Assistant Professor, PhD, Department of Biotechnology, Microbiology and Forensic Sciences, School of Sciences, Noida International University, Plot 1, Yamuna Expy, Sector 17A, Greater Noida 203201, Uttar Pradesh, India. dharmsheel.shrivastav1@gmail.com
Key Words	Diabetic nephropathy; Type 2 diabetes; SLC30A8; Epigenetic; MiRNAs; ZnT8
Core Tip	Diabetic nephropathy is a major complication of type 2 diabetes mellitus. This review highlights the emerging role of the miR-375/miR-765–PDX-1–SLC30A8/ZnT8 regulatory axis in β-cell dysfunction and renal injury. Targeting this pathway through epigenetic and gene-based therapies may restore insulin homeostasis and offer novel strategies for diabetic nephropathy management.
Citation	Sharma VK, Beg MMA, Singh S, Singh SK, Shrivastav D. SLC30A8 (ZnT8) at the crossroads of epigenetics and microRNA regulation in type 2 diabetes and nephropathy. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.122565
PDF	122565-in-press.pdf

Received	2026-04-22 01:57
Peer-Review Started	2026-04-27 10:04
First Decision by Editorial Office Director	2026-06-04 11:34
Return for Revision	2026-06-05 04:56
Revised	2026-06-10 05:17
Publication Fee Transferred
Second Decision by Editor	2026-07-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-09 08:14
Articles in Press	2026-07-09 08:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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