Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	122608
DOI	10.4251/wjgo.122608
Country	Czech Republic

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Cohort Study
Article Title	Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Jing Ye, Esraa Ali, Sergii Pavlov, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Petr Hošek, Ondřej Daum, Václav Liška, Kari Hemminki and Andriy Trailin
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Health of Czech Republic NU21-03-00506 Ministry of Health of Czech Republic NW24-03-00521 Cooperatio Program, Research Area SURG SALVAGE Project (OP JAK; co-financed by the European Union and the State Budget of the Czech Republic) CZ.02.01.01/00/22_008/0004644 Integration of Biomedical Research and Health Care in the Pilsen Metropolitan Area (co-funded by the European Union and by the State Budget of the Czech Republic) CZ.02.01.01/00/23_021/0008828
Corresponding Author	Andriy Trailin, Laboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, Pilsen 32300, Czech Republic. andriy.trailin@lfp.cuni.cz
Key Words	Neutrophils; Mast cells; Primary colorectal cancer; Liver metastases; Adjacent non-tumor mucosa; Tumor microenvironment; Survival
Core Tip	Densities of polymorphonuclear neutrophils (PMNs) and mast cells (MCs) showed distinct spatial patterns across colorectal cancer (CRC) progression, with PMNs increasing and MCs decreasing from nontumor mucosa through primary CRC (pCRC) to liver metastases (LM). MCs in pCRC exhibited protumor associations with survival, whereas PMNs showed context-dependent survival associations, being unfavorable in stage I-III pCRC and synchronous LM but favorable in metachronous LM. These findings highlight dynamic, stage- and site-specific roles of PMNs and MCs and after validation may serve as prognostic biomarkers for CRC patients.
Citation	Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Daum O, Liška V, Hemminki K, Trailin A. Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.122608
PDF	122608-in-press.pdf

Received	2026-04-23 07:35
Peer-Review Started	2026-04-23 07:38
First Decision by Editorial Office Director	2026-06-10 02:22
Return for Revision	2026-06-10 06:51
Revised	2026-06-15 08:54
Publication Fee Transferred	2026-07-22 07:44
Second Decision by Editor	2026-08-05 03:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:35
Articles in Press	2026-08-05 10:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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