Publication Name	World Journal of Gastroenterology
Manuscript ID	122612
DOI	10.3748/wjg.122612
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	CLIF-AKI score predicts KDIGO stage 3 acute kidney injury in intensive care unit patients with acute-on-chronic liver failure
Manuscript Source	Unsolicited Manuscript
All Author List	Nan Wang, You-Wen Tan, Peng-Fei Zhang, Xing-Bei Zhou and Li Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Zhenjiang Science and Technology Plan for Social Development SH2024074
Corresponding Author	Peng-Fei Zhang, Department of Hepatology, Zhenjiang Third People’s Hospital, Affiliated Zhenjiang Third Hospital of Jiangsu University, No. 300 Daijiamen Road, Zhenjiang 212009, Jiangsu Province, China. jsdxzpf@163.com
Key Words	Acute kidney injury; Acute-on-chronic liver failure; Predictive score; Risk stratification; Intensive care unit
Core Tip	Patients with acute-on-chronic liver failure admitted to the intensive care unit are at high risk of developing stage 3 acute kidney injury (AKI); however, reliable tools for early prediction remain limited. We developed and externally validated the chronic liver failure organ failure-AKI score to predict stage 3 AKI in patients with acute-on-chronic liver failure. The score demonstrated good discrimination and clinical utility, and outperformed the PIRO model and existing prognostic scores in the external validation cohort. We also developed a point-based scoring system and an online calculator to facilitate its implementation in clinical practice.
Citation	Wang N, Tan YW, Zhang PF, Zhou XB, Zhu L. CLIF-AKI score predicts KDIGO stage 3 acute kidney injury in intensive care unit patients with acute-on-chronic liver failure. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122612
PDF	122612-in-press.pdf

Received	2026-04-24 06:53
Peer-Review Started	2026-04-24 06:54
First Decision by Editorial Office Director	2026-06-10 08:25
Return for Revision	2026-06-10 08:25
Revised	2026-07-07 14:49
Publication Fee Transferred	2026-07-25 13:16
Second Decision by Editor	2026-07-31 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-31 09:52
Articles in Press	2026-07-31 09:52
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ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	Patients with acute-on-chronic liver failure admitted to the intensive care unit are at high risk of developing stage 3 acute kidney injury (AKI); however, reliable tools for early prediction remain limited. We developed and externally validated the chronic liver failure organ failure-AKI score to predict stage 3 AKI in patients with acute-on-chronic liver failure. The score demonstrated good discrimination and clinical utility, and outperformed the PIRO model and existing prognostic scores in the external validation cohort. We also developed a point-based scoring system and an online calculator to facilitate its implementation in clinical practice.
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