Publication Name	World Journal of Gastroenterology
Manuscript ID	122668
DOI	10.3748/wjg.122668
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Zfp36 zinc finger CCCH-type inhibits gastric cancer progression by upregulating lipase G and binding its 3’ untranslated region
Manuscript Source	Unsolicited Manuscript
All Author List	Peng-Jie Yu, Sheng-Mao Zhu, Bao-Jia Cai, Xiao-Ming Ma, Wen-Jie Qiao, Jing-Jun Han and Cheng-Wu Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Qinghai Provincial Department of Science and Technology 2023-ZJ-787
Corresponding Author	Cheng-Wu Zhang, Professor, Department of Gastrointestinal Oncology Surgery, Qinghai University Affiliated Hospital (School of Clinical Medicine), No. 29 Tongren Road, Chengdong District, Xining 810001, Qinghai Province, China. 952068360@qq.com
Key Words	Zfp36 zinc finger CCCH-type; Gastric cancer; Lipase G; RNA-binding protein; 3’ untranslated region
Core Tip	Zfp36 zinc finger CCCH-type (ZFP36), an RNA-binding protein, has an unclear role in gastric cancer. Here, ZFP36 overexpression in AGS cells suppressed proliferation, migration, and invasion, as well as G0/G1-phase arrest and apoptosis induction, while also inhibiting xenograft tumor growth. Integrated RNA sequencing and improved RNA immunoprecipitation sequencing identified lipase G (LIPG) as a direct target, with ZFP36 binding to its 3’ untranslated region to enhance LIPG expression. In vivo, LIPG was upregulated in ZFP36-overexpressing tumors. These findings demonstrate that ZFP36 inhibits gastric cancer progression by upregulating LIPG, revealing a potential therapeutic axis.
Citation	Yu PJ, Zhu SM, Cai BJ, Ma XM, Qiao WJ, Han JJ, Zhang CW. Zfp36 zinc finger CCCH-type inhibits gastric cancer progression by upregulating lipase G and binding its 3’ untranslated region. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122668
PDF	122668-in-press.pdf

Received	2026-04-27 08:22
Peer-Review Started	2026-04-27 08:23
First Decision by Editorial Office Director	2026-05-28 10:37
Return for Revision	2026-05-28 10:37
Revised	2026-06-26 09:36
Publication Fee Transferred	2026-07-13 02:26
Second Decision by Editor	2026-07-28 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:06
Articles in Press	2026-07-28 13:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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