Publication Name	World Journal of Stem Cells
Manuscript ID	122681
DOI	10.4252/wjsc.122681
Country	China

Category	Surgery
Manuscript Type	Basic Study
Article Title	Umbilical cord mesenchymal stem cell-derived exosomes ameliorate parathyroid ischemic injury via inhibition of the neutrophil cytosolic factor 4-nuclear factor kappa B pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Hao-Han Huang, Ming-Yao Meng, Qiu-Yu Meng, Chuan-Yuan Liu, Shao-Hao Cheng, Guang-Min Yang, Gui-Yao Wu, Ruo-Chuan Cheng, Hui Gao, Bin Liu, Ting-Ting Yang, Xiao-Dan Wang and Yan-Jun Su
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81760142, 82360159 Yunnan Provincial Science and Technology Department 202301AY070001-047 Xingdian Talent Support Program and 535 Talent Project of First Affiliated Hospital of Kunming Medical University 2023535D07 Yunnan Clinical Medical Center for Endocrine and Metabolic Diseases YWLCYXZXXYS20221005
Corresponding Author	Yan-Jun Su, Director, MD, Professor, Department of Thyroid Surgery, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming 650032, Yunnan Province, China. suyanjun20042003@aliyun.com
Key Words	Umbilical cord mesenchymal stem cell-derived exosomes; Parathyroid ischemic injury; Neutrophil cytosolic factor 4-nuclear factor kappa B pathway; Parathyroid cells; Oxidative stress
Core Tip	The treatment of hypoparathyroidism (hypoPT) after surgery is a major clinical challenge. In this study, a rabbit model of parathyroid ischemia was established by ligating the upper limb vessels of the parathyroid glands. Exosomes derived from umbilical cord mesenchymal stem cells (UCMSC-Exo) were injected into the parathyroid capsule. The results showed that this method could significantly restore parathyroid hormone and serum calcium levels, and alleviate the pathological damage of parathyroid tissue. Mechanism studies revealed that UCMSC-Exo exerted its protective effect by inhibiting the neutrophil cytosolic factor 4-nuclear factor kappa B signaling pathway. This research suggests that UCMSC-Exo may be a promising therapeutic strategy for preventing postoperative hypoPT.
Citation	Huang HH, Meng MY, Meng QY, Liu CY, Cheng SH, Yang GM, Wu GY, Cheng RC, Gao H, Liu B, Yang TT, Wang XD, Su YJ. Umbilical cord mesenchymal stem cell-derived exosomes ameliorate parathyroid ischemic injury via inhibition of the neutrophil cytosolic factor 4-nuclear factor kappa B pathway. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.122681
PDF	122681-in-press.pdf

Received	2026-05-06 05:56
Peer-Review Started	2026-05-06 05:56
First Decision by Editorial Office Director
Return for Revision	2026-06-24 02:16
Revised	2026-07-07 19:06
Publication Fee Transferred	2026-10-03 11:27
Second Decision by Editor	2026-10-23 08:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 03:08
Articles in Press	2026-11-02 03:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com