Publication Name	World Journal of Clinical Oncology
Manuscript ID	122710
DOI	10.5306/wjco.122710
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Multicenter nomogram integrating clinicopathological features for prognosis in stage II-III deficient/microsatellite instability-high rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	De-Yao Zhang, Yi-Jun Liao, Xin Tang, Gong Chen and Rong-Xin Zhang
Funding Agency and Grant Number
Corresponding Author	Rong-Xin Zhang, MD, Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. zhangrx@sysucc.org.cn
Key Words	Mismatch repair; Microsatellite instability; Rectal cancer; Lymphovascular invasion; Perineural invasion; Nomogram; Recurrence-free survival
Core Tip	Deficient/microsatellite instability-high rectal cancer has distinct biological features, but postoperative risk assessment is still largely based on tumor-node-metastasis stage. This multicenter exploratory cohort highlights lymphovascular invasion as an independent predictor of recurrence-free survival in stage II-III deficient/microsatellite instability-high rectal adenocarcinoma, while perineural invasion showed no independent prognostic value. A preliminary nomogram integrating tumor stage, lymphovascular invasion, perineural invasion, and body mass index offers a practical framework for recurrence risk stratification, but requires external validation before clinical use.
Citation	Zhang DY, Liao YJ, Tang X, Chen G, Zhang RX. Multicenter nomogram integrating clinicopathological features for prognosis in stage II-III deficient/microsatellite instability-high rectal cancer. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.122710
PDF	122710-in-press.pdf

Received	2026-04-28 02:09
Peer-Review Started	2026-04-28 02:33
First Decision by Editorial Office Director	2026-05-22 02:28
Return for Revision	2026-05-22 02:28
Revised	2026-06-10 14:01
Publication Fee Transferred	2026-06-18 15:18
Second Decision by Editor	2026-07-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-09 03:14
Articles in Press	2026-07-09 03:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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