Publication Name	World Journal of Clinical Oncology
Manuscript ID	122727
DOI	10.5306/wjco.122727
Country	China

Category	Oncology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Role of perioperative carcinoembryonic Antigen in guiding adjuvant chemotherapy for colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Ting Zheng and Guang-Yao Li
Funding Agency and Grant Number
Corresponding Author	Guang-Yao Li, Associate Chief Physician, Department of Gastrointestinal Surgery, The Second People’s Hospital of Wuhu, 259 Jiuhua Middle Road, Jinghu District, Wuhu City, Anhui Province, China, Wuhu 241000, Hubei Province, China. liguangyao@whsdermyy23.wecom.work
Key Words	Postoperative carcinoembryonic antigen; Colorectal cancer; Adjuvant chemotherapy; Circulating tumor DNA; Risk stratification
Core Tip	Postoperative carcinoembryonic antigen (CEA) is a simple and inexpensive marker, but its use for guiding adjuvant chemotherapy in colorectal cancer still requires caution. The retrospective design, variable timing of postoperative CEA testing, and absence of treatment–biomarker interaction analysis may limit the strength of the conclusion. Future studies should standardize CEA measurement and combine it circulating tumor DNA to improve postoperative risk stratification.
Citation	Zheng WT, Li GY. Letter to the Editor: Role of perioperative carcinoembryonic Antigen in guiding adjuvant chemotherapy for colorectal cancer. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.122727
PDF	122727-in-press.pdf

Received	2026-04-27 05:53
Peer-Review Started	2026-04-27 05:54
First Decision by Editorial Office Director
Return for Revision	2026-06-28 12:43
Revised	2026-07-11 13:34
Publication Fee Transferred
Second Decision by Editor	2026-07-20 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-20 06:36
Articles in Press	2026-07-20 06:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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