Publication Name	World Journal of Translational Medicine
Manuscript ID	122755
DOI	10.5528/wjtm.122755
Country	India

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Beyond the bladder: Recognising glomerular hematuria and the role of genetic testing in clinical practice
Manuscript Source	Invited Manuscript
All Author List	Sairam Bashyam and Mythri Shankar
Funding Agency and Grant Number
Corresponding Author	Mythri Shankar, Associate Professor, Department of Nephrology, Institute of Nephrourology, Victoria Hospital Campus, Bengaluru 560102, Karnataka, India. mythri.nish@gmail.com
Key Words	Microhematuria; Glomerular hematuria; Genetic testing; Alport syndrome; Next-generation sequencing; Whole-exome sequencing; Nephrology referral
Core Tip	This review challenges the traditional perception of isolated hematuria as benign by emphasizing the critical role of genetic testing in precision nephrology. We propose a practical traffic-light framework to guide test ordering, enabling clinicians to recognize glomerular hematuria needing nephrology referral, select between targeted panels and whole-exome sequencing, and incorporate pre-test counselling in busy practice. The approach integrates cascade screening, underscores the impact of molecular diagnosis on immunosuppression, and addresses safeguarding living-related donors through genetic evaluation. By bridging urology and nephrology, it supports personalized care, avoids invasive procedures, enables early nephroprotection, and improves prognostication in hereditary kidney disease overall outcomes.
Citation	Bashyam S, Shankar M. Beyond the bladder: Recognising glomerular hematuria and the role of genetic testing in clinical practice. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.122755
PDF	122755-in-press.pdf

Received	2026-04-27 08:31
Peer-Review Started	2026-04-27 08:33
First Decision by Editorial Office Director	2026-05-31 11:39
Return for Revision	2026-06-01 14:01
Revised	2026-06-14 18:48
Publication Fee Transferred
Second Decision by Editor	2026-07-08 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-08 07:06
Articles in Press	2026-07-08 07:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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