Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	122786
DOI	10.4291/wjgp.122786
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Evidence Review
Article Title	Microplastics and nanoplastics in inflammatory bowel disease: Mechanistic plausibility, human evidence and future research priorities
Manuscript Source	Invited Manuscript
All Author List	Richard Hall, Michael Colwill, Kamal Patel, Sailish Honap and Andrew Poullis
Funding Agency and Grant Number
Corresponding Author	Richard Hall, Research Fellow, Department of Gastroenterology, St George’s University Hospitals NHS Foundation Trust, Blackshaw Road, London SW17 0QT, United Kingdom. richard.hall@stgeorges.nhs.uk
Key Words	Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Microplastics; Nanoplastics
Core Tip	Microplastics and nanoplastics are emerging as ubiquitous environmental contaminants of potential relevance in inflammatory bowel disease (IBD). Experimental evidence suggests that intestinal exposure may promote dysbiosis, mucus barrier disruption, epithelial permeability and immune activation, all pathways implicated in IBD pathogenesis. Current evidence supports biological plausibility but is limited to simplified preclinical models and small observational human studies. Prospective human studies are needed to investigate whether micro- and nanoplastics may contribute to IBD onset, activity or progression.
Citation	Hall R, Colwill M, Patel K, Honap S, Poullis A. Microplastics and nanoplastics in inflammatory bowel disease: Mechanistic plausibility, human evidence and future research priorities. World J Gastrointest Pathophysiol 2026; In press DOI: https://doi.org/10.4291/wjgp.122786
PDF	122786-in-press.pdf

Received	2026-04-28 03:44
Peer-Review Started	2026-04-28 03:45
First Decision by Editorial Office Director	2026-05-22 09:35
Return for Revision	2026-05-22 09:35
Revised	2026-06-03 16:32
Publication Fee Transferred
Second Decision by Editor	2026-06-24 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-24 08:43
Articles in Press	2026-06-24 08:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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