Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	122796
DOI	10.4251/wjgo.122796
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Peripheral blood marker changes predict response and prognosis in locally advanced gastric cancer with neoadjuvant sintilimab plus XELOX
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Wu, Mi-Mi Xu, Guo-Lin Wang, Wen-Di Du and Xin-Hui Su
Funding Agency and Grant Number
Corresponding Author	Xin-Hui Su, Academic Fellow, MD, PhD, Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. suxinhui@zju.edu.cn
Key Words	Gastric cancer; Peripheral blood; Neoadjuvant therapy; Immunotherapy; Sintilimab; Gastric signet ring cell carcinoma; Gastric carcinoma subtypes
Core Tip	This study investigated the changes in peripheral blood inflammatory markers and T-cell subsets in patients with gastric cancer at baseline and after neoadjuvant chemotherapy with sintilimab combined with XELOX. Results indicate that high post-treatment monocyte-to-lymphocyte ratio levels are associated with a favorable treatment response, a greater relative change in the proportion of CD8+ T cells may be associated with better prognosis, and diffuse-type gastric cancer may be associated with poorer clinical outcomes. These easily detectable biomarkers offer a new perspective for predicting treatment response and assessing prognosis; however, further validation is required.
Citation	Wu Y, Xu MM, Wang GL, Du WD, Su XH. Peripheral blood marker changes predict response and prognosis in locally advanced gastric cancer with neoadjuvant sintilimab plus XELOX. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.122796
PDF	122796-in-press.pdf

Received	2026-04-29 03:02
Peer-Review Started	2026-04-29 03:02
First Decision by Editorial Office Director	2026-05-27 01:40
Return for Revision	2026-05-27 01:40
Revised	2026-06-11 14:56
Publication Fee Transferred	2026-06-15 09:08
Second Decision by Editor	2026-06-30 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-30 05:40
Articles in Press	2026-06-30 05:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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