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Articles in Press
10/8/2026 8:50:14 AM | Browse: 5 | Download: 0
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Cluster-based metabolic subphenotypes and projected cross-organ risk in Chinese adults with prediabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shu-Han Zhang, Li-Ping Yu, Jin-Ping Zhang, Lu-Lu Song, Li-Li Wu, Zhao-Qing Li, Yi-Fan He, Rui-Fen Deng, Wan-Lu Ma, Cong Zhang, Xian Jin and Bo Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High-Level Hospital Clinical Research Funding |
No. 2025-NHLHCRF-JBGS-B-WZ-01 |
| National Key Research and Development Program of China |
No. 2018YFC1313902 |
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| Corresponding Author |
Bo Zhang, MD, Professor, Department of Endocrinology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang District, Beijing 100029, China. zhangbo@zryhyy.com.cn |
| Key Words |
Prediabetic state; Metabolic subphenotypes; Cluster analysis; Cardiovascular-kidney-metabolic syndrome; Cardiovascular diseases; Chronic renal insufficiency; Liver fibrosis; Insulin deficiency |
| Core Tip |
Prediabetes is not a uniform metabolic state. In this Chinese multicenter cohort, cluster-defined subphenotypes showed distinct projected cardio–kidney–liver risk-score patterns. Mild age-related dysmetabolism represented a broad, age-loaded projected-risk subtype across Framingham, chronic kidney disease prognosis consortium, and fibrosis-4 domains. Severe insulin deficiency showed the most unexpected signal: Despite lower adiposity and lack of a classical insulin-resistant phenotype, it remained enriched for projected chronic kidney disease risk and fibrosis-4-defined liver fibrosis-risk signal. These findings connect prediabetes subphenotyping with an integrated organ-risk framework and support prospective validation of subtype-informed risk assessment before overt diabetes. |
| Citation |
Zhang SH, Yu LP, Zhang JP, Song LL, Wu LL, Li ZQ, He YF, Deng RF, Ma WL, Zhang C, Jin X, Zhang B. Cluster-based metabolic subphenotypes and projected cross-organ risk in Chinese adults with prediabetes. World J Diabetes 2026; In press
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Received |
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2026-04-29 01:40 |
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Peer-Review Started |
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2026-04-30 08:14 |
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First Decision by Editorial Office Director |
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2026-06-08 06:18 |
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Return for Revision |
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2026-06-08 06:18 |
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Revised |
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2026-07-04 15:44 |
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Publication Fee Transferred |
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2026-07-19 09:56 |
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Second Decision by Editor |
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2026-08-10 09:31 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 08:50 |
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Articles in Press |
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2026-10-08 08:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
