Publication Name	World Journal of Stem Cells
Manuscript ID	122823
DOI	10.4252/wjsc.122823
Country	China

Category	Otorhinolaryngology
Manuscript Type	Review
Article Title	Stem cell-based strategies for hearing restoration: Current advances and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Yan-Ji Qu, Jia-Yu Wang, Zhe Wang, Wei Yao and Zhong-Fang Xia
Funding Agency and Grant Number	Funding Agency Grant Number Funding for Scientific Research Projects from Wuhan Municipal Health Commission WX23Q01 Natural Science Foundation of Hubei Province of China 2023AFB328, 2025AFB091
Corresponding Author	Zhong-Fang Xia, Chief, PhD, Department of Otolaryngology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 100 Xianggang Road, Wuhan 430022, Hubei Province, China. zhfxia2005@163.com
Key Words	Hearing loss; Stem cell; Cochlear organoids; Hair cell regeneration; Extracellular vesicles
Core Tip	Sensorineural hearing loss remains difficult to reverse as current treatments mainly compensate for dysfunction rather than restore damaged cochlear cells. This review highlights recent progress in stem cell-based hearing restoration, focusing on stem cell sources, auditory cell fate regulation, delivery optimization, immune microenvironment modulation, and cochlear organoids. It further emphasizes the emerging value of organoid platforms and cell-free strategies in advancing translational and regenerative therapies for hearing loss.
Citation	Qu YJ, Wang JY, Wang Z, Yao W, Xia ZF. Stem cell-based strategies for hearing restoration: Current advances and future perspectives. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.122823
PDF	122823-in-press.pdf

Received	2026-05-07 07:48
Peer-Review Started	2026-05-07 07:48
First Decision by Editorial Office Director	2026-05-22 09:46
Return for Revision	2026-05-22 09:46
Revised	2026-06-04 15:28
Publication Fee Transferred
Second Decision by Editor	2026-06-30 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-30 07:12
Articles in Press	2026-06-30 07:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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