Publication Name	World Journal of Gastroenterology
Manuscript ID	122826
DOI	10.3748/wjg.122826
Country	China

Category	Medicine, General & Internal
Manuscript Type	Case Report
Article Title	Superior mesenteric arteriovenous fistula as a rare manifestation of Cowden syndrome: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Heng Zhao, Jing Qi, Jin-Ming Hu, Ying-Ying Zhao, Ming-Qi Liu, Li Deng, Fan Zhang, Shan-shan Gao and Kun Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82203149 and No. 82000580 Shandong Medical Association No. YXH2022ZX02113 Shandong Research Hospital Association No. 2023012
Corresponding Author	Kun Li, Chief Physician, MD, PhD, Professor, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Street Address: No. 324, Jingwu Weigi Road, Huaiyin District, Jinan, Shandong Province, China, Jinan 250021, Shandong Province, China. 1483@sdhospital.com.cn
Key Words	Cowden syndrome; PTEN mutation; Superior mesenteric arteriovenous fistula; Transjugular intrahepatic portosystemic shunt; Vascular malformation; Case report
Core Tip	We report the first documented case of Cowden syndrome (CS) complicated by a superior mesenteric arteriovenous fistula. A systematic review of the literature identified 13 cases, in addition to the present case, of CS associated with gastrointestinal and hepatic vascular anomalies. These findings suggest that these lesions may be linked to the imbalance of angiogenesis and vascular remodeling induced by PTEN mutations, thereby expanding the known vascular phenotypic spectrum of CS.
Citation	Zhao ZH, Qi J, Hu JM, Zhao YY, Liu MQ, Deng L, Zhang F, Gao SS, Li K. Superior mesenteric arteriovenous fistula as a rare manifestation of Cowden syndrome: A case report and review of literature. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122826
PDF	122826-in-press.pdf

Received	2026-05-06 08:56
Peer-Review Started	2026-05-06 08:59
First Decision by Editorial Office Director	2026-06-09 10:14
Return for Revision	2026-06-09 10:14
Revised	2026-06-23 09:36
Publication Fee Transferred
Second Decision by Editor	2026-07-08 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-08 07:59
Articles in Press	2026-07-08 07:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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