Publication Name	World Journal of Clinical Oncology
Manuscript ID	122832
DOI	10.5306/wjco.122832
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Feng Deng, Lei Zhao, Ye Yuan, Li-Kun Li, Mu-Ya Ge, Liang-Ding Dou, Jin-Wen Zhang, Dai Wang, Dong-Bei Guo, Ran An, Yong-Xing Zhang and Bo Song
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82272349
Corresponding Author	Bo Song, Chief Physician, PhD, Professor, Air Force Hospital of Eastern Theater, Nanjing University of Chinese Medicine, No.1 Changfu Road, MaLu Road, Nanjing 230032, Jiangsu Province, China. 23822520@qq.com
Key Words	Lung cancer; A-kinase anchoring protein 95; Degradation of cyclins; SCFFBXL2 and SCFFBXO31; CPSF5/6
Core Tip	This study links mechanistic findings to clinical evidence in lung cancer. Immunohistochemical analysis of 40 tumor specimens showed that AKAP95 was negatively correlated with the SCFFBXO31, whereas Cx43 was positively correlated with SCFFBXO31. Complementary cell experiments supported opposing effects of AKAP95 and Cx43 on SCFFBXO31 expression. Together, these findings provide clinical support for a proposed pathway through which the AKAP95-Cx43 axis regulates cyclin D1 degradation and cell-cycle progression.
Citation	Deng ZF, Zhao L, Yuan Y, Li LK, Ge MY, Dou LD, Zhang JW, Wang D, Guo DB, Ran An, Zhang YX, Song B. Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.122832
PDF	122832-in-press.pdf

Received	2026-05-06 07:38
Peer-Review Started	2026-05-06 07:40
First Decision by Editorial Office Director
Return for Revision	2026-07-23 02:01
Revised	2026-08-05 15:08
Publication Fee Transferred	2026-08-21 08:55
Second Decision by Editor	2026-09-15 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-15 09:18
Articles in Press	2026-09-15 09:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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