Publication Name	World Journal of Clinical Cases
Manuscript ID	122847
DOI	10.12998/wjcc.122847
Country	United Kingdom

Category	Emergency Medicine
Manuscript Type	Systematic Reviews
Article Title	Effectiveness and safety of antifibrinolytic agents in the management of pulmonary haemorrhage: A systematic review with narrative synthesis
Manuscript Source	Invited Manuscript
All Author List	Yasmin Kabir and Jonathan Soldera
Funding Agency and Grant Number
Corresponding Author	Jonathan Soldera, Gastroenterology and Acute Medicine, University of South Wales in association with Learna Ltd., University of South Wales, Llantwit Road, Pontypridd, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com
Key Words	Pulmonary hemorrhage; Hemoptysis; Tranexamic acid; Antifibrinolytic agents; Administration; Inhalation
Core Tip	This systematic review with narrative synthesis shows that the apparent effect of tranexamic acid (TXA) on haemoptysis outcomes depends heavily on clinical context: Nebulised TXA improves bleeding control in stable, non-massive haemoptysis, whereas higher mortality reported with TXA in intensive care cohorts most likely reflects confounding by indication rather than drug harm. Route, severity, and population must therefore be considered together when interpreting TXA evidence, rather than treating haemoptysis as a single condition or TXA exposure as uniform across settings.
Citation	Kabir Y, Soldera J. Effectiveness and safety of antifibrinolytic agents in the management of pulmonary haemorrhage: A systematic review with narrative synthesis. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.122847
PDF	122847-in-press.pdf

Received	2026-04-30 03:37
Peer-Review Started	2026-04-30 03:38
First Decision by Editorial Office Director
Return for Revision	2026-06-22 01:19
Revised	2026-07-05 12:17
Publication Fee Transferred
Second Decision by Editor	2026-07-20 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-20 07:05
Articles in Press	2026-07-20 07:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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