Publication Name	World Journal of Gastroenterology
Manuscript ID	122850
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Add-on trimebutine-maleate does not improve tolerability or eradication in bismuth quadruple therapy for Helicobacter pylori
Manuscript Source	Unsolicited Manuscript
All Author List	Eun Jeong Gong and Chang Seok Bang
Funding Agency and Grant Number	Funding Agency Grant Number Samil Pharmaceutical Company
Corresponding Author	Chang Seok Bang, MD, PhD, Department of Internal Medicine, Hallym University College of Medicine, Sakju-ro 77, Chuncheon 24253, Gangwon-do, South Korea. cloudslove@naver.com
Key Words	Helicobacter pylori; Eradication therapy; Bismuth quadruple therapy; Trimebutine; Adverse events
Core Tip	This is the first prospective randomized controlled trial to evaluate add-on trimebutine maleate as an adjuvant to 14-day bismuth quadruple therapy for Helicobacter pylori eradication. Despite trimebutine’s widespread off-label use, add-on treatment did not reduce treatment-emergent adverse events, improve medication adherence, or increase eradication rates, with point estimates tightly clustered around the null. Although the trial was underpowered owing to early termination, these findings do not support routine adjunctive use of trimebutine and redirect attention toward mucosa- and microbiota-directed strategies with proven benefit.
Citation	Gong EJ, Bang CS. Add-on trimebutine-maleate does not improve tolerability or eradication in bismuth quadruple therapy for Helicobacter pylori. World J Gastroenterol 2026; In press

Received	2026-04-30 01:19
Peer-Review Started	2026-04-30 01:20
First Decision by Editorial Office Director
Return for Revision	2026-07-10 01:21
Revised	2026-07-13 05:42
Publication Fee Transferred	2026-07-27 01:56
Second Decision by Editor	2026-08-31 03:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-31 08:11
Articles in Press	2026-08-31 08:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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