Publication Name	World Journal of Gastroenterology
Manuscript ID	122851
DOI	10.3748/wjg.122851
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Clinical Trial
Article Title	Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Na Zhu, Yong-Bing Wang, Lu Li, Ya-Di Ren, Rao-Rao Wang, Ying-Lan Ji, Ya-Ping Wang, Hao-Yu Zhai and Yong Jiang
Funding Agency and Grant Number	Funding Agency Grant Number Tianjin Municipal Education Commission Scientific Research Program 2023KJ025
Corresponding Author	Yong Jiang, PhD, Professor, Department of Gastroenterology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Tianjin 300202, China. jiangyong-612@163.com
Key Words	Minocycline; Low-dose; Helicobacter pylori; Eradication therapy; Adverse events
Core Tip	The optimal dose of minocycline in bismuth-containing quadruple therapy remains uncertain. This study demonstrates that a low-dose minocycline-based regimen is noninferior to the standard-dose regimen in treatment-naïve Helicobacter pylori infection, while offering a superior safety profile and better cost-effectiveness, supporting its clinical utility.
Citation	Zhu YN, Wang YB, Li L, Ren YD, Wang RR, Ji YL, Wang YP, Zhai HY, Jiang Y. Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122851
PDF	122851-in-press.pdf

Received	2026-04-30 03:26
Peer-Review Started	2026-04-30 03:26
First Decision by Editorial Office Director	2026-06-09 10:00
Return for Revision	2026-06-09 10:00
Revised	2026-06-23 08:59
Publication Fee Transferred	2026-06-30 14:39
Second Decision by Editor	2026-07-06 03:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-06 07:36
Articles in Press	2026-07-06 07:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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