Publication Name	World Journal of Gastroenterology
Manuscript ID	122855
DOI	10.3748/wjg.122855
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Longitudinal serum total cholesterol patterns and subsequent clinical relapse in ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Ji-Yeon Kim, Min-Ji Kim, Minjee Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Eun Ran Kim and Ji Eun Kim
Funding Agency and Grant Number
Corresponding Author	Eun Ran Kim, MD, PhD, Professor, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea. er.kim@samsung.com
Key Words	Ulcerative colitis; Clinical relapse; Serum total cholesterol; Longitudinal trajectory; Endoscopic improvement
Core Tip	Most studies link serum lipid levels, including total cholesterol (TC), to concurrent inflammatory activity, not to changes after endoscopic improvement. In this retrospective cohort of patients with ulcerative colitis, baseline serum TC did not distinguish outcomes, whereas exploratory trajectory analysis showed divergent serial TC patterns according to subsequent clinical relapse status. In the time-varying Cox model, each 1 mmol/L increase in updated TC was associated with a 1.31-fold higher hazard of clinical relapse. Supportive landmark analyses showed similar associations using maximal TC. Serial serum TC patterns may provide complementary information associated with relapse risk.
Citation	Kim JY, Kim MJ, Kim M, Hong SN, Chang DK, Kim YH, Kim ER, Kim JE. Longitudinal serum total cholesterol patterns and subsequent clinical relapse in ulcerative colitis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122855
PDF	122855-in-press.pdf

Received	2026-05-08 06:35
Peer-Review Started	2026-05-08 06:36
First Decision by Editorial Office Director	2026-05-26 09:40
Return for Revision	2026-05-26 09:40
Revised	2026-06-13 06:54
Publication Fee Transferred	2026-06-22 23:29
Second Decision by Editor	2026-07-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 08:41
Articles in Press	2026-07-02 08:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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