Publication Name	World Journal of Clinical Oncology
Manuscript ID	122878
DOI	10.5306/wjco.122878
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Case Report
Article Title	Tubulocystic renal cell carcinoma with aggressive behavior-insights from molecular profiling and single-cell analysis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Chong-Liang Zheng, Ze Wang, Gao-Lei Liu, Hai-Yang Xiao, Xiao-Du Xie, Zi-Qian Wang, Yao Zhang, Jun Zhang, Jun Jiang, Qiu-Li Liu and Wei-Hua Lan
Funding Agency and Grant Number	Funding Agency Grant Number NoncommunicableChronic Diseases-National Science and Technology Major Project 2026ZD0553703 National Natural Science Foundation of China 82473441 National Natural Science Foundation of China 82172807
Corresponding Author	Wei-Hua Lan, Department of Urology, Daping Hospital, Army Medical University, Daping Hospital, Army Medical University, at 10#, Changjiang Zhilu, Yuzhong District, Chongqing 400042, China. lanweihua@tmmu.edu.cn
Key Words	Metastatic tubulocystic renal cell carcinoma; Tumor microenvironment; Genetic profiling; Single-cell RNA sequencing; Case report
Core Tip	Tubulocystic renal cell carcinoma (TRCC) is generally considered an indolent malignancy. However, we report an exceptional aggressive case characterized by rapid recurrence and metastasis. Using next-generation sequencing and single-cell RNA sequencing, we identified a germline missense mutation in fumarate hydratase and somatic alterations in AFF3, MDM2, and LRP1B. The recurrent tumor exhibited enhanced angiogenic activity and an immunosuppressive microenvironment enriched in naïve T cells and SPP1⁺ tumor-associated macrophages. These findings provide insights into the molecular mechanisms underlying aggressive TRCC and highlight potential therapeutic targets for future clinical management.
Citation	Zheng CL, Wang Z, Liu GL, Xiao HY, Xie XD, Wang ZQ, Zhang Y, Zhang J, Jiang J, Liu QL, Lan WH. Tubulocystic renal cell carcinoma with aggressive behavior-insights from molecular profiling and single-cell analysis: A case report. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.122878
PDF	122878-in-press.pdf

Received	2026-05-09 07:46
Peer-Review Started	2026-05-09 07:46
First Decision by Editorial Office Director
Return for Revision	2026-06-24 03:06
Revised	2026-07-21 04:44
Publication Fee Transferred	2026-08-10 09:28
Second Decision by Editor	2026-08-21 02:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-21 10:23
Articles in Press	2026-08-21 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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