Publication Name	World Journal of Gastroenterology
Manuscript ID	122954
DOI	10.3748/wjg.122954
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Bile acid metabolic disorders and their role in hepatic encephalopathy of cirrhosis
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Jie Huo, Zi-Xin Liang, Jing-Xuan Bian, Jing-Tian Zhang, Li Cha, Qi-Yue Yang, Chun-Juan Zhao, Jin-Yu Li, Dui-Ping Feng and Long Gao
Funding Agency and Grant Number	Funding Agency Grant Number the Shanxi Provincial Clinical Research Center for Interventional Medicine No. 202204010501004 the Central Government Guiding Local Science and Technology Development Funds No. YDZJSX20231B010
Corresponding Author	Long Gao, Associate Chief Physician, PhD, Department of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, No. 56 Xinjian South Road, Yingze District, Taiyuan 030001, Shanxi Province, China. gaolong@sxmu.edu.cn
Key Words	Liver cirrhosis; Bile acids; Hepatic encephalopathy; Gut microbiota; Blood-brain barrier; Gut-liver-brain axis
Core Tip	Cirrhosis disrupts bile acid (BA) homeostasis, creating a vicious cycle with gut dysbiosis and barrier injury. Accumulated toxic BAs cross the blood-brain barrier and modulate neuroinflammation via farnesoid X receptor, Takeda G protein-coupled receptor 5, and Sphingosine-1-phosphate receptor 2 signaling, synergizing with hyperammonemia to drive hepatic encephalopathy. BA profiles vary by cirrhosis etiology, offering diagnostic and prognostic potential. Targeting BA pathways represents a promising therapeutic strategy for hepatic encephalopathy.
Citation	Huo YJ, Liang ZX, Bian JX, Zhang JT, Cha L, Yang QY, Zhao CJ, Li JY, Feng DP, Gao L. Bile acid metabolic disorders and their role in hepatic encephalopathy of cirrhosis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122954
PDF	122954-in-press.pdf

Received	2026-05-12 05:52
Peer-Review Started	2026-05-12 05:53
First Decision by Editorial Office Director
Return for Revision	2026-06-30 06:20
Revised	2026-07-12 17:23
Publication Fee Transferred	2026-07-21 08:02
Second Decision by Editor	2026-07-27 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 12:58
Articles in Press	2026-07-28 12:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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