Publication Name	World Journal of Clinical Cases
Manuscript ID	122960
DOI	10.12998/wjcc.122960
Country	India

Category	Oncology
Manuscript Type	Randomized Controlled Trial
Article Title	Aprepitant as add-on to standard antiemetic regimen for concurrent chemoradiotherapy induced nausea vomiting in head and neck cancer
Manuscript Source	Invited Manuscript
All Author List	Neetu Gupta, Shailley Sehgal and Niti Mittal
Funding Agency and Grant Number
Corresponding Author	Niti Mittal, Associate Professor, DM, Department of Pharmacology, Postgraduate Institute of Medical Sciences, Medical Road, Null, Rohtak 124001, Haryana, India. drnitimittal@uhsr.ac.in
Key Words	Concurrent chemoradiotherapy; Aprepitant; Head and neck cancer; Antiemetic regimen; Complete response; Complete protection; Rescue medication
Core Tip	This is the first randomised, double-blind, placebo-controlled trial evaluating aprepitant as add-on to standard antiemetic therapy in locally advanced head and neck squamous cell carcinoma patients receiving weekly cisplatin-based concurrent chemoradiotherapy. Addition of aprepitant significantly improved acute-phase complete response (97.7% vs 81.4%), complete protection in both phases, and nausea intensity without compromising safety or tolerability, supporting consideration of neurokinin-1 receptor antagonists as part of antiemetic prophylaxis in this setting, while larger studies are needed to confirm benefits during the delayed phase.
Citation	Gupta N, Sehgal S, Mittal N. Aprepitant as add-on to standard antiemetic regimen for concurrent chemoradiotherapy induced nausea vomiting in head and neck cancer. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.122960
PDF	122960-in-press.pdf

Received	2026-05-07 07:18
Peer-Review Started	2026-05-07 07:18
First Decision by Editorial Office Director
Return for Revision	2026-06-22 01:53
Revised	2026-07-05 14:39
Publication Fee Transferred
Second Decision by Editor	2026-07-16 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-16 07:37
Articles in Press	2026-07-16 07:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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