Publication Name	World Journal of Gastroenterology
Manuscript ID	122971
DOI	10.3748/wjg.122971
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Nomogram integrating prognostic immune-inflammatory-nutritional score with clinicopathological parameters for predicting post-transplantation outcomes in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Can Huang, Han-Xuan Wang, Yang Zhao, Xian-Liang Li, Qiang He, Ren Lang and Lin Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82370665
Corresponding Author	Lin Zhou, Division of Hepatobiliary and Pancreaticosplenic Surgery, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing 100020, China. richard_fmmu@126.com
Key Words	Hepatocellular carcinoma; Nomogram; Liver transplantation; Nutrition; Immunity; Inflammation
Core Tip	Although nutritional, immune and inflammatory status affect hepatocellular carcinoma (HCC) prognosis, composite indicators reflecting these factors remain unreported. We retrospectively enrolled 269 HCC patients undergoing liver transplantation and constructed a prognostic immune-inflammatory-nutritional (PIIN) score using least absolute shrinkage and selection operator regression on routine blood test-derived indicators. A PIIN-based prediction model incorporating PIIN score, tumor number, tumor size, alpha fetoprotein and differentiation was also established. A high PIIN score independently predicted worse overall and disease-free survival, showed favorable discrimination, calibration, and clinical utility superior to conventional criteria, and may serve as a practical tool for evaluating post-transplant prognosis in HCC.
Citation	Huang JC, Wang HX, Zhao Y, Li XL, He Q, Lang R, Zhou L. Nomogram integrating prognostic immune-inflammatory-nutritional score with clinicopathological parameters for predicting post-transplantation outcomes in hepatocellular carcinoma. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122971
PDF	122971-in-press.pdf

Received	2026-05-07 02:11
Peer-Review Started	2026-05-07 02:12
First Decision by Editorial Office Director
Return for Revision	2026-06-29 02:47
Revised	2026-07-03 16:46
Publication Fee Transferred	2026-07-22 15:02
Second Decision by Editor	2026-07-29 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-29 10:01
Articles in Press	2026-07-29 10:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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