Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	122992
DOI	10.4251/wjgo.122992
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Direct gastric invasion is associated with poor prognosis in esophageal squamous cell carcinoma involving the lower-third esophagus
Manuscript Source	Unsolicited Manuscript
All Author List	Yao-Kuang Wang, Chun-Sheng Shen, Fang-Jung Yu, Yi-Hsun Chen, Wei-Chung Chen, Jui Ying Lee, Ming-Tsang Wu and I-Chen Wu
Funding Agency and Grant Number	Funding Agency Grant Number Kaohsiung Medical University Hospital KMUH114-4R02 National Science and Technology Council NTSC 113-2221-E037-005-MY2 Taiwan’s Ministry of Science and Technology MOST 110-2314-B-037-099 Kaohsiung Medical University KMU-TC114A205-1 Kaohsiung Medical University Hospital KMUH-DK(C)-114008
Corresponding Author	I-Chen Wu, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100 Tzyou 1st Road, Kaohsiung 807377, Taiwan. minicawu@gmail.com
Key Words	Chemoradiotherapy; Surgery; Esophageal squamous cell carcinoma; Gastric invasion; Survival
Core Tip	Direct gastric invasion is a rare but clinically important manifestation of esophageal squamous cell carcinoma (ESCC). In our cohort, patients with direct gastric invasion of ESCC typically presented with advanced-stage disease and experienced significantly poorer survival than those without gastric invasion. Although patients treated with chemoradiotherapy followed by surgery demonstrated longer survival, this finding should be interpreted cautiously because of the small sample size and potential treatment selection bias. Overall, our results suggest that direct gastric invasion may serve as a marker of poor prognosis and warrants further investigation in larger prospective studies.
Citation	Wang YK, Shen CS, Yu FJ, Chen YH, Chen WC, Lee JY, Wu MT, Wu IC. Direct gastric invasion is associated with poor prognosis in esophageal squamous cell carcinoma involving the lower-third esophagus. World J Gastrointest Oncol 2026; In Press DOI: https://doi.org/10.4251/wjgo.122992
PDF	122992-in-press.pdf

Received	2026-05-09 06:38
Peer-Review Started	2026-05-09 06:39
First Decision by Editorial Office Director	2026-06-02 07:35
Return for Revision	2026-06-02 07:35
Revised	2026-06-15 02:23
Publication Fee Transferred	2026-07-09 01:09
Second Decision by Editor	2026-07-15 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-15 06:49
Articles in Press	2026-07-15 06:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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