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Publication Name World Journal of Gastroenterology
Manuscript ID 123000
DOI 10.3748/wjg.123000
Country China
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Glasgow prognostic score as a predictor of decompensation in patients with primary biliary cholangitis
Manuscript Source Unsolicited Manuscript
All Author List Man Huang, Feng Guo, Li-Gong Bian, Chang-Hui Wu, Wen Zou, De Duan, Yuan Tang, Shun-Yu Chen, Meng-Yao Zheng, Jun-Kun Niu and Hong-Tao Lei
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research Foundation of Education Department of Yunnan Province No. 2025J0329
Scientific Research Foundation of Education Department of Yunnan Province No. 2025J0270
Yunnan Fundamental Research Kunming Medical University Projects No. 202601AY070001-193
Yunnan Provincial Postdoctoral Innovation Support Program
Doctoral Research Project of the Second Affiliated Hospital of Kunming Medical University No. 2025BS04
Corresponding Author Hong-Tao Lei, School of Public Health, Kunming Medical University, No. 1168 Chunrong West Road, Chenggong District, Kunming 650500, Yunnan Province, China. 20191209@kmmu.edu.cn
Key Words Primary biliary cholangitis; Decompensated cirrhosis; Glasgow prognostic score; Predictive value; Modified primary biliary cholangitis
Core Tip This multicenter cohort study evaluated the predictive value of the Glasgow prognostic score (GPS) and its derivatives modified GPS (mGPS) and high-sensitivity mGPS (hs-mGPS) for hepatic decompensation in primary biliary cholangitis (PBC). GPS integrates C-reactive protein (CRP) and albumin to reflect systemic inflammation and nutritional status. In 762 patients with compensated PBC, GPS, mGPS, and hs-mGPS were independent predictors of decompensation, with GPS demonstrating the highest predictive accuracy. These findings highlight GPS as a simple, cost-effective tool for early risk stratification and personalized management in PBC.
Citation Huang M, Guo F, Bian LG, Wu CH, Zou W, Duan D, Tang Y, Chen SY, Zheng MY, Niu JK, Lei HT. Glasgow prognostic score as a predictor of decompensation in patients with primary biliary cholangitis. World J Gastroenterol 2026; In press
PDF 123000-in-press.pdf
Received
2026-05-07 08:05
Peer-Review Started
2026-05-07 08:05
First Decision by Editorial Office Director
2026-06-15 06:06
Return for Revision
2026-06-15 06:06
Revised
2026-06-29 02:40
Publication Fee Transferred
2026-08-12 04:33
Second Decision by Editor
2026-09-02 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-04 09:13
Articles in Press
2026-09-04 09:13
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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