Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123002
DOI	10.4251/wjgo.123002
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Ping Fang, Shu-Ni Liu, Feng-Ping Liu, Jing-Wen Gong, Yi-Fan Zhang, Jun-Hui Lu, Jing-Wei Liu, Qing Wang and Xing Chen
Funding Agency and Grant Number	Funding Agency Grant Number Construction and Validation of a Prognostic Risk Scoring Model Related to Cuproptosis-Characteristic Genes in Gastric Cancer SYYYRC-2022002 Evaluation of the Efficacy and Safety of Different Doses of Saccharomyces boulardii Combined with Dual Regimens for the Eradication of Helicobacter pylori ITT-2025-125
Corresponding Author	Xing Chen, MD, Department of Gastroenterology, The First Hospital of Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan 030001, Shanxi Province, China. chen0419xing@163.com
Key Words	Cuproptosis; Copper metabolism; Gastric cancer; Tumor microenvironment; Immunotherapy; Copper ionophores; Copper chelators; Nanomedicine; Biomarkers
Core Tip	Cuproptosis connects copper imbalance with mitochondrial metabolic vulnerability, angiogenesis, immune regulation, and treatment resistance in gastric cancer. This review summarizes copper homeostasis, protein lipoylation, oncogenic signaling, the tumor microenvironment, and copper-modulating therapies. It highlights copper ionophores, chelators, nanomedicine, and biomarkers, including ferredoxin 1, amine oxidase copper-containing 1, integrin beta 1, and serpin family E member 1, for patient stratification and rational combination therapy while emphasizing toxicity and translational challenges.
Citation	Fang YP, Liu SN, Liu FP, Gong JW, Zhang YF, Lu JH, Liu JW, Wang Q, Chen X. Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123002
PDF	123002-in-press.pdf

Received	2026-05-06 03:21
Peer-Review Started	2026-05-06 03:21
First Decision by Editorial Office Director	2026-05-15 09:33
Return for Revision	2026-05-15 09:33
Revised	2026-05-21 06:32
Publication Fee Transferred	2026-05-25 06:38
Second Decision by Editor	2026-06-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-15 06:25
Articles in Press	2026-06-15 06:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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