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Articles in Press
9/4/2026 9:13:53 AM | Browse: 8 | Download: 1
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Integrating proteomics, metabolomics, and molecular docking to elucidate the mechanism of Jiangtang Qingre formula against metabolic dysfunction-associated steatohepatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Juan Zhou, Jin-Lin Wu, Hang Wang, Rui Han, Cai Tang, Fang Fang and Dan-Ping Zhu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chongqing Clinical Research Center for Metabolic Diseases (Integrated Traditional Chinese and Western Medicine) |
SQMS2025DXB-006 |
| Chongqing Clinical Research Center for Metabolic Diseases (Integrated Traditional Chinese and Western Medicine) |
SQMS2026DXB-001 |
| Chongqing Clinical Research Center for Metabolic Diseases (Integrated Traditional Chinese and Western Medicine) |
SQMS2026DXB-003 |
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| Corresponding Author |
Dan-Ping Zhu, Department of Endocrinology and Metabolism, Chongqing Traditional Chinese Medicine Hospital, Department of Endocrinology and Metabolism, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400021, China. zdp790203@163.com., Chongqing 400021, China. zdp790203@163.com |
| Key Words |
Metabolic dysfunction-associated steatohepatitis; Jiangtang Qingre formula; Multi-omics; Oxidative stress; Leiomodin 3; Timosaponins |
| Core Tip |
This study demonstrated that Jiangtang Qingre formula (JQF) ameliorates metabolic dysfunction-associated steatohepatitis through multi-target mechanisms. Multi-omics revealed arachidonic acid metabolism, and glutathione metabolism, with multiple targets implicated including Lmod3. Molecular docking confirmed timosaponins exhibited the strongest binding affinity to these targets. Knockdown of Lmod3 partially alleviated free fatty acids-induced AML12 cell injury, an effect further augmented by JQF. Additionally, timosaponin A III and timosaponin B II were effectively absorbed into the bloodstream and enriched in the liver, while their secondary metabolite sarsasapogenin was detected at high abundance in feces, further supporting the role of timosaponins as key pharmacologically active substances. |
| Citation |
Zhou LJ, Wu JL, Wang H, Han R, Tang C, Fang F, Zhu DP. Integrating proteomics, metabolomics, and molecular docking to elucidate the mechanism of Jiangtang Qingre formula against metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; In press
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| PDF |
123033-in-press.pdf
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Received |
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2026-05-07 08:18 |
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Peer-Review Started |
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2026-05-07 08:19 |
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First Decision by Editorial Office Director |
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2026-06-03 11:26 |
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Return for Revision |
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2026-06-03 11:26 |
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Revised |
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2026-07-01 09:50 |
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Publication Fee Transferred |
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2026-07-07 04:50 |
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Second Decision by Editor |
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2026-09-02 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-04 09:13 |
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Articles in Press |
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2026-09-04 09:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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