Publication Name	World Journal of Stem Cells
Manuscript ID	123046
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Induced pluripotent stem cells in Hirschsprung disease: Modeling, mechanisms, and translational challenges
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan-Xiang Qiu, Zheng-Ke Zhi, Yu-Mu Leng, Xin-Tao Zhang, Chun-Xia Du, Jie Tang, Hong-Xing Li and Wei-Bing Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82001590, 82270540
Corresponding Author	Hong-Xing Li, Associate Professor, MD, PhD, Department of Pediatric Surgery, Children’s Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing 210008, Jiangsu Province, China. hx8817@njmu.edu.cn
Key Words	Hirschsprung disease; Induced pluripotent stem cells; Disease modeling; Drug screening; Cell therapy
Core Tip	Patient-derived induced pluripotent stem cell (iPSC) platforms provide human models for linking Hirschsprung disease (HSCR)-associated genetic backgrounds with enteric neural crest cell (ENCC) developmental phenotypes and tissue-level interactions. This review summarizes iPSC platform establishment, two-dimensional ENCC models, recombined and bioengineered gut systems, drug screening, and cell-based regenerative strategies. We emphasize genetic complexity, reproducibility, functional maturation, electrophysiological validation, and translational feasibility. Current iPSC-based HSCR models are most useful for mechanistic investigation and preclinical development, whereas drug screening and cell therapy remain exploratory.
Citation	Qiu YX, Zhi ZK, Leng YM, Zhang XT, Du CX, Tang J, Li HX, Tang WB. Induced pluripotent stem cells in Hirschsprung disease: Modeling, mechanisms, and translational challenges. World J Stem Cells 2026; In press

Received	2026-05-11 06:25
Peer-Review Started	2026-05-11 06:26
First Decision by Editorial Office Director	2026-05-27 06:59
Return for Revision	2026-05-27 08:10
Revised	2026-06-17 21:42
Publication Fee Transferred	2026-06-28 12:14
Second Decision by Editor	2026-07-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-13 06:40
Articles in Press	2026-07-13 06:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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