Publication Name	World Journal of Psychiatry
Manuscript ID	123050
DOI	10.5498/wjp.123050
Country	China

Category	Clinical Neurology
Manuscript Type	Minireviews
Article Title	Oral microbiome dysbiosis, neuroinflammation, and psychiatric disorders: A review of current progress
Manuscript Source	Unsolicited Manuscript
All Author List	Xue Wang, Jia-Bai Liu, Xue-Mei Zhao, Jie Zhang, Jing-Hong Yin and Jia-Yin Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Jilin Province Science and Technology Development Program Project YDZJ202401090ZYTS
Corresponding Author	Jia-Yin Zhang, Consultant, Department of Stomatology, Jilin Province FAW General Hospital, No. 2643 Dongfeng Street, Lvyuan District, Changchun 130000, Jilin Province, China. zhangjiayin315@163.com
Key Words	Psychiatric disorders; Neuroinflammatorty diseases; Oral microbiota; Oral-gut-brain axis; Periodontitis; Major depressive disorder; Schizophrenia; Autism spectrum disorder; Cytokines
Core Tip	Oral microbiome dysbiosis can drive neuroinflammation and contribute to psychiatric disorders via three key pathways: Direct bloodstream invasion, neural retrograde transport along trigeminal and olfactory nerves, and disruption of the oral-gut-brain axis. Recent animal evidence showing that Lactobacillus supplementation alleviates anxiety- and depression-like behaviors reinforces the translational potential of targeting the oral microbiota. This minireview integrates these mechanisms and highlights the oral cavity as an accessible, modifiable target for novel diagnostic and adjunctive therapeutic strategies in psychiatry.
Citation	Wang X, Liu JB, Zhao XM, Zhang J, Yin JH, Zhang JY. Oral microbiome dysbiosis, neuroinflammation, and psychiatric disorders: A review of current progress. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.123050
PDF	123050-in-press.pdf

Received	2026-06-10 11:10
Peer-Review Started	2026-06-10 11:10
First Decision by Editorial Office Director
Return for Revision	2026-06-30 06:50
Revised	2026-07-10 07:49
Publication Fee Transferred	2026-07-23 01:41
Second Decision by Editor	2026-07-30 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-30 10:46
Articles in Press	2026-07-30 10:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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