Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123088
DOI	10.4251/wjgo.123088
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Long Guo, Yun-Peng Qi, Qiang Zhang, Jian-Jun Hao, Yu Yang, Ming-Yang Zhang and Zhen-Tao He
Funding Agency and Grant Number
Corresponding Author	Zhen-Tao He, Academic Fellow, Department of General Surgery I, Third Affiliated Hospital of Qiqihar Medical University, No. 27 Taishun Street, Tiefeng District, Qiqihar 161000, Heilongjiang Province, China. hezhentao1983@qmu.edu.cn
Key Words	Colon cancer; TRAP1; HMGB1; P62; Immunohistochemistry; Reverse transcription-polymerase chain reaction; Prognosis
Core Tip	This study investigated the expression of TRAP1, HMGB1, and p62 in colon cancer tissues, all of which were significantly upregulated compared with adjacent normal mucosa at both protein and mRNA levels. Their high expressions were closely associated with adverse clinicopathological features including poor differentiation, lymph node metastasis, and advanced TNM stage. TRAP1 was identified as an independent predictor for lymph node metastasis and poor overall survival, showing superior prognostic value. HMGB1 also independently predicted lymph node metastasis, while p62 was correlated with tumor progression but lacked independent prognostic significance. These findings suggest that TRAP1, HMGB1, and p62 serve as promising biomarkers for colon cancer, with TRAP1 being particularly valuable for prognostic assessment.
Citation	Guo HL, Qi YP, Zhang Q, Hao JJ, Yang Y, Zhang MY, He ZT. Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123088
PDF	123088-in-press.pdf

Received	2026-05-09 10:59
Peer-Review Started	2026-05-09 10:59
First Decision by Editorial Office Director	2026-05-27 01:47
Return for Revision	2026-05-27 01:47
Revised	2026-06-08 11:24
Publication Fee Transferred	2026-06-17 05:33
Second Decision by Editor	2026-07-28 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:01
Articles in Press	2026-07-28 13:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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