Publication Name	World Journal of Hepatology
Manuscript ID	123089
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Effects of pegylated interferon on T cell receptor fingerprints in chronic hepatitis B patients with/without surface antigen clearance
Manuscript Source	Unsolicited Manuscript
All Author List	Kun-Yan Hao, Lei Tang, Guo-Bing Chen, Wei Guo, Zhan-Hui Wang, Li-Peng Mao and Yue-Cheng Yu
Funding Agency and Grant Number	Funding Agency Grant Number Science Foundation of Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University 22JCYYYB11
Corresponding Author	Yue-Cheng Yu, PhD, Center of Hepatology and Department of Infectious Disease, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 34 Yang-Gong-Jing, Qin-Huai Region, Nanjing 210002, Jiangsu Province, China. gslsycy@163.com
Key Words	Hepatitis B surface antigen clearance; Pegylated interferon α-2b; T cell receptor diversity; Complementarity-determining region 3; RNA sequencing; Fingerprints
Core Tip	This study compared T cell receptor (TCR) fingerprints of chronic hepatitis B (CHB) patients with or without hepatitis B surface antigen (HBsAg) clearance following treatment with nucleos(t)ide analogues combined with pegylated interferon alpha-2b (PegIFNα-2b). No baseline virological/biochemical differences was found between the groups. Patients achieving HBsAg clearance exhibited markedly higher TCR α/β chain diversity, more unique clonotypes and greater repertoire overlap. These immune signatures may serve as potential reference indicators for PegIFNα-2b treatment response in CHB patients.
Citation	Hao KY, Tang L, Chen GB, Guo W, Wang ZH, Mao LP, Yu YC. Effects of pegylated interferon on T cell receptor fingerprints in chronic hepatitis B patients with/without surface antigen clearance. World J Hepatol 2026; In press

Received	2026-05-08 06:38
Peer-Review Started	2026-05-08 06:38
First Decision by Editorial Office Director	2026-06-08 09:50
Return for Revision	2026-06-09 11:57
Revised	2026-06-18 15:03
Publication Fee Transferred	2026-06-30 13:36
Second Decision by Editor	2026-07-07 03:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-07 06:38
Articles in Press	2026-07-07 06:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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