Publication Name	World Journal of Gastroenterology
Manuscript ID	123092
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Development and validation of a prognostic prediction model for alpha-fetoprotein-negative hepatocellular carcinoma with microvascular invasion after surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Min-Jun Liao, Yu Zhou, Zi-Long Wang, Xiao-Xiao Wang, Xin Ai, Lin-Na Song, Ran Fei, Xu Cong, Feng Liu, Peng-Peng Zhu, Hong-Song Chen, Wei-Jia Liao and Hui-Ying Rao
Funding Agency and Grant Number	Funding Agency Grant Number National Key R&D Program of China 2022YFA1303804 the Dongguan Social Development Technology Project 20221800906062 the Taikang Health Investment Youth Medical Research Initiation Fund 2025030 the Research Fund of the Second Affiliated Hospital, Xi’an Jiaotong University YJ(YB)202518
Corresponding Author	Hui-Ying Rao, Peking University Hepatology Institute, Infectious Disease and Hepatology Center of Peking University People's Hospital, Beijing Key Laboratory of Innovative Drug and Device Translation in Endocrine and Metabolic Diseases, Peking University People's Hospital, No. 133 Fuchengmennei Street, Xicheng District, Beijing 100044, China. rao.huiying@163.com
Key Words	Hepatocellular carcinoma; Alpha-fetoprotein-negative; Microvascular invasion; Radical surgery; Prognosis
Core Tip	Alpha-fetoprotein-negative hepatocellular carcinoma (AFP-NHCC) combined with microvascular invasion (MVI) constitutes a distinct subgroup, biomarkers or prognostic indicators for AFP-NHCC patients with MVI are not investigated and defined yet. TGN model provides an effective tool for risk stratification in patients with AFP-NHCC and MVI, and may be used to guide postoperative management and surveillance strategies.
Citation	Liao MJ, Zhou Y, Wang ZL, Wang XX, Ai X, Song LN, Fei R, Cong X, Liu F, Zhu PP, Chen HS, Liao WJ, Rao HY. Development and validation of a prognostic prediction model for alpha-fetoprotein-negative hepatocellular carcinoma with microvascular invasion after surgery. World J Gastroenterol 2026; In press

Received	2026-05-18 07:41
Peer-Review Started	2026-05-18 07:42
First Decision by Editorial Office Director
Return for Revision	2026-07-03 06:37
Revised	2026-07-16 09:47
Publication Fee Transferred	2026-07-28 04:15
Second Decision by Editor	2026-08-26 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-26 08:39
Articles in Press	2026-08-26 08:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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