Publication Name	World Journal of Psychiatry
Manuscript ID	123127
DOI	10.5498/wjp.123127
Country	China

Category	Anesthesiology
Manuscript Type	Basic Study
Article Title	Ulinastatin modulates Klotho homeostasis and autophagy to mitigate cognitive dysfunction in aged perioperative neurocognitive disorder
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Ji, Kun-Yuan Xu, Meng-Meng Zhang, Chun-Yan Zhang, Ke-Liang Lu and Xiao Song
Funding Agency and Grant Number
Corresponding Author	Ke-Liang Lu, Department of Anesthesiology, Affiliated Hospital of Shandong Second Medical University, detailed address, Weifang 261053, Shandong Province, China. jjfs888@sdsmu.edu.cn
Key Words	Klotho; Ulinastatin; Perioperative neurocognitive disorder; Autophagy
Core Tip	Perioperative neurocognitive disorder (PND) is a long-term perioperative complication that affects elderly surgical patients. As the aging population continues to grow, the prevention and treatment of PND have become important issues to address. Research has shown that ulinastatin (UTI) significantly reduces the incidence of PND in elderly patients undergoing various types of surgery. However the underlying mechanisms of this effect remain unclear. In the present study, Klotho protein is associated with many neurological diseases. we aimed to investigate the relationship between UTI and Klotho protein in PND and to determine its underlying mechanism. Furthermore, UTI treatment improve the level of Autophagy and inhibiting microglial activation and Klotho expression in the hippocampus.
Citation	Ji Y, Xu KY, Zhang MM, Zhang CY, Lu KL, Song X. Ulinastatin modulates Klotho homeostasis and autophagy to mitigate cognitive dysfunction in aged perioperative neurocognitive disorder. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.123127
PDF	123127-in-press.pdf

Received	2026-05-09 07:06
Peer-Review Started	2026-05-09 07:06
First Decision by Editorial Office Director	2026-05-22 06:11
Return for Revision	2026-05-22 06:11
Revised	2026-06-26 08:50
Publication Fee Transferred	2026-08-25 01:01
Second Decision by Editor	2026-10-09 03:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:37
Articles in Press	2026-10-09 09:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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