Publication Name	World Journal of Nephrology
Manuscript ID	123149
DOI	10.5527/wjn.123149
Country	Pakistan

Category	Transplantation
Manuscript Type	Review
Article Title	Kidney transplantation in systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis: Challenges and clinical perspectives
Manuscript Source	Invited Manuscript
All Author List	Tabassum Elahi, Saima Ahmed and Muhammed Mubarak
Funding Agency and Grant Number
Corresponding Author	Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Key Words	Autoimmune kidney diseases; End-stage kidney disease; Kidney transplantation; Lupus nephritis; Recurrence risk; Systemic lupus erythematosus; Vasculitis
Core Tip	Autoimmune kidney diseases such as lupus nephritis (LN) and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are the major cause of end-stage kidney disease. Kidney transplantation (KT) is an important therapeutic option for these patients. Disease quiescence before transplantation is crucial in patients with LN. Novel biomarkers such as monocyte chemoattractant protein-1, B-cell activating factor, and matrix metalloproteinase-7 help in predicting the post-transplant recurrence. Outcomes may improve with preemptive KT and individualized immunosuppression. In ANCA-associated vasculitis, 12 months of stable remission is recommended, despite the presence of ANCA positivity. The relapse risk is minimized with advanced immunosuppressive regimens, while for post-transplant recurrence, rituximab offers an option. For optimizing long-term graft survival, modifying strategies and emerging cell-based therapies hold promise.
Citation	Elahi T, Ahmed S, Mubarak M. Kidney transplantation in systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis: Challenges and clinical perspectives. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.123149
PDF	123149-in-press.pdf

Received	2026-05-18 07:41
Peer-Review Started	2026-05-18 07:42
First Decision by Editorial Office Director
Return for Revision	2026-06-29 06:02
Revised	2026-07-11 11:52
Publication Fee Transferred
Second Decision by Editor	2026-08-05 03:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:47
Articles in Press	2026-08-05 10:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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