Publication Name	World Journal of Gastroenterology
Manuscript ID	123192
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Distinct clinical profile of Wilson disease-related cirrhosis: Insights from a propensity score-matched multicenter study
Manuscript Source	Unsolicited Manuscript
All Author List	Peng-Yue Zhang, Shu-Qi Wu, Da-Lei Li, Zheng-Qi Gao, Chang-Kang Chen, Chun-Hui Tao, Xiao-Dan Hong and Zhen-Hua Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Outstanding Project of Jianghuai Talent Training Program in Anhui Province Health Research Program of Anhui AHWJ2023A30107 National Natural Science Foundation Incubation Program of the Second Affiliated Hospital of Anhui Medical University 2023GQFY01
Corresponding Author	Zhen-Hua Zhang, Chief Physician, PhD, Postdoc, Professor, Department of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. zhangzhenhua@ahmu.edu.cn
Key Words	Wilson disease; Cirrhosis; Hepatitis B virus; Autoimmune; Alcohol; Complications
Core Tip	Wilson disease (WD) is a rare inherited metabolic liver disease that commonly presents as cirrhosis. A brief non-invasive model for WD-related cirrhosis was constructed using age, platelet count, and routine laboratory parameters. After propensity score matching for age and sex, two key determinants of WD phenotypic expression, WD cirrhosis showed a distinct complication profile, with higher risks of hepatic failure and hepatic encephalopathy, but lower rates of esophagogastric variceal bleeding and hepatocellular carcinoma compared with other etiologies.
Citation	Zhang PY, Wu SQ, Li DL, Gao ZQ, Chen CK, Tao CH, Hong XD, Zhang ZH. Distinct clinical profile of Wilson disease-related cirrhosis: Insights from a propensity score-matched multicenter study. World J Gastroenterol 2026; In press

Received	2026-05-12 05:53
Peer-Review Started	2026-05-12 05:55
First Decision by Editorial Office Director
Return for Revision	2026-06-26 01:32
Revised	2026-07-08 14:01
Publication Fee Transferred	2026-07-23 10:30
Second Decision by Editor	2026-08-26 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-26 08:38
Articles in Press	2026-08-26 08:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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