Publication Name	World Journal of Psychiatry
Manuscript ID	123228
DOI	10.5498/wjp.123228
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinical symptom complexity and treatment challenges in perinatal depression comorbid with anxiety or post-traumatic stress disorder
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Juan Wu and Xin Xie
Funding Agency and Grant Number
Corresponding Author	Xin Xie, Associate Chief Physician, Department of Obstetrics, Affiliated Women’s Hospital of Jiangnan University, No. 48 Huaishu Lane, Wuxi 214002, Jiangsu Province, China. xiexin0303@163.com
Key Words	Perinatal depression; Comorbidity; Anxiety; Post-traumatic stress disorder; Childhood trauma; Birth trauma
Core Tip	Perinatal depression frequently co-occurs with anxiety or posttraumatic stress disorder, forming a high risk clinical profile marked by greater symptom severity and markedly lower treatment response rates-particularly in cases with triple comorbidity. Childhood trauma, traumatic birth experiences, low perceived social support, and severe baseline depression independently predict poor outcomes. Routine screening for these comorbidities, paired with traumainformed assessment of early life and obstetric experiences, is essential to guide personalized interventions and optimize maternal and infant prognosis.
Citation	Wu MJ, Xie X. Clinical symptom complexity and treatment challenges in perinatal depression comorbid with anxiety or post-traumatic stress disorder. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.123228
PDF	123228-in-press.pdf

Received	2026-06-30 10:34
Peer-Review Started	2026-06-30 10:34
First Decision by Editorial Office Director
Return for Revision	2026-07-15 08:47
Revised	2026-07-27 14:40
Publication Fee Transferred	2026-08-04 02:14
Second Decision by Editor	2026-08-07 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-10 11:13
Articles in Press	2026-08-10 11:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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