Publication Name	World Journal of Gastroenterology
Manuscript ID	123234
DOI	10.3748/wjg.123234
Country	China

Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Antibiotic-associated gut dysbiosis and intestinal failure in critically ill patients: Mechanisms and interventions
Manuscript Source	Unsolicited Manuscript
All Author List	Liang Tian and Shan-Shan Xu
Funding Agency and Grant Number
Corresponding Author	Liang Tian, Associate Faculty, Chief Pharmacist, Department of Pharmacy, Shanghai Deji Hospital, Qingdao University Shanghai Clinical Medical College, No. 378 Gulang Road, Putuo District, Shanghai 200331, China. tianliang@shneuro.org
Key Words	Anti-bacterial agents; Gut microbiota dysbiosis; Critically ill patients; Intestinal failure; Short-chain fatty acids; Molecular mechanisms; Antibiotic stewardship
Core Tip	Broad-spectrum antibiotics precipitate a four-stage pathological cascade in critically ill patients: Gut microbiota dysbiosis, short-chain fatty acid depletion, intestinal barrier injury, and systemic inflammatory activation, ultimately driving multiple organ dysfunction syndrome. This review maps each cascade stage to a specific intervention, proposing a stage-based therapeutic framework. Three clinical priorities: Microbiome surveillance after prolonged antibiotic exposure, early enteral nutrition within 48 hours, and integration of days-of-therapy/antibiotic spectrum index metrics into stewardship decisions.
Citation	Tian L, Xu SS. Antibiotic-associated gut dysbiosis and intestinal failure in critically ill patients: Mechanisms and interventions. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123234
PDF	123234-in-press.pdf

Received	2026-05-13 07:13
Peer-Review Started	2026-05-13 07:14
First Decision by Editorial Office Director
Return for Revision	2026-06-29 08:27
Revised	2026-06-30 15:00
Publication Fee Transferred	2026-07-06 12:10
Second Decision by Editor	2026-07-24 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 12:55
Articles in Press	2026-07-28 12:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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