Publication Name	World Journal of Clinical Cases
Manuscript ID	123291
DOI	10.12998/wjcc.123291
Country	China

Category	Pediatrics
Manuscript Type	Case Report
Article Title	Fish oil emulsion for reversal of intestinal failure-associated liver disease in preterm infants: Three case reports and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Ju Chen, Zhuo-Ga Danzeng, Peng-Fei Ye, Xiao-Ming Xu, Juan Liang and Li Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Clinical research funding of West China Second University Hospital, Sichuan University KL073 National Natural Science Foundation of China (General Program) 81501304
Corresponding Author	Juan Liang, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20 Section 3, Renmin South Road, Wuhou District, Chengdu 610041, Sichuan Province, China. liangjuan079@163.com
Key Words	Intestinal failure-associated liver disease; Fish oil lipid emulsion; Parenteral nutrition; Preterm infants; Case report
Core Tip	Prolonged parenteral nutrition in preterm infants can lead to intestinal failure-associated liver disease (IFALD). We describe three preterm infants with severe IFALD who were treated with pure fish oil lipid emulsion (FO-ILE) at 2 g/kg/day—higher than conventional protocols. This approach was associated with a rapid decline in direct bilirubin levels and was well tolerated without evidence of essential fatty acid deficiency, growth impairment, or bleeding complications. To the best of our knowledge, this report is among the first reports of high-dose FO-ILE for severe IFALD in preterm infants, a vulnerable population because of hepatic immaturity.
Citation	Chen HJ, Danzeng ZG, Ye PF, Xu XM, Liang J, Zhang L. Fish oil emulsion for reversal of intestinal failure-associated liver disease in preterm infants: Three case reports and review of literature. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.123291
PDF	123291-in-press.pdf

Received	2026-05-14 07:28
Peer-Review Started	2026-05-14 07:28
First Decision by Editorial Office Director	2026-05-19 02:08
Return for Revision	2026-05-19 02:08
Revised	2026-06-03 06:16
Publication Fee Transferred	2026-06-04 12:03
Second Decision by Editor	2026-06-26 02:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-26 07:42
Articles in Press	2026-06-26 07:42
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ISSN	2307-8960 (online)
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