Publication Name	World Journal of Clinical Oncology
Manuscript ID	123351
DOI	10.5306/wjco.123351
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Neoadjuvant intra-arterial chemoembolization improves tumor pathological regression and survival in Borrmann type IV gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Xing Wu, Hou-Dun Yang, Jiang Min, Chao Yuan, Lian-Shuo Li, Wei Zhang and Yue Tong
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Municipal Science and Technology Bureau CSTB2025NSCQ-GPX1134
Corresponding Author	Yue Tong, Academic Fellow, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. natual101@gmail.com
Key Words	Borrmann type IV; Gastric cancer; Intra-arterial chemoembolization; Gastrectomy; Lymph node
Core Tip	Borrmann type IV gastric cancer has a poor prognosis because of its diffuse and infiltrative growth pattern. In this retrospective cohort of 70 patients, neoadjuvant intra-arterial chemoembolization followed by gastrectomy achieved an objective response rate of 40.0% with manageable toxicity. Primary-tumor pathological response was associated with better survival in unadjusted analyses, whereas N-stage regression remained independently associated with improved overall survival and disease-free survival after multivariable adjustment. Postoperative complications were associated with worse outcomes. These findings support N-stage regression as a clinically relevant prognostic marker and warrant prospective evaluation of intra-arterial chemoembolization as a therapeutic strategy for Borrmann type IV gastric cancer.
Citation	Wu XX, Yang HD, Min J, Yuan C, Li LS, Zhang W, Tong Y. Neoadjuvant intra-arterial chemoembolization improves tumor pathological regression and survival in Borrmann type IV gastric cancer. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.123351
PDF	123351-in-press.pdf

Received	2026-05-18 07:41
Peer-Review Started	2026-05-18 07:42
First Decision by Editorial Office Director
Return for Revision	2026-07-13 03:27
Revised	2026-07-27 03:10
Publication Fee Transferred	2026-08-14 08:04
Second Decision by Editor	2026-08-20 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-20 08:42
Articles in Press	2026-08-20 08:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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