Publication Name	World Journal of Hepatology
Manuscript ID	123353
DOI	10.4254/wjh.123353
Country	Thailand

Category	Gastroenterology & Hepatology
Manuscript Type	Translational Research
Article Title	Cost-utility analysis of glucagon-like peptide-1 receptor agonists for type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease in Thailand
Manuscript Source	Unsolicited Manuscript
All Author List	Sirada Limwongse, Paninnuch Chatpattanasiri, Phonnaphat Phuphuang, Krisada Tungthaweethong, Keerati Sutheerayongprasert, Watkornphat Aunprom-Me, Chayanis Kositamongkol and Pochamana Phisalprapa
Funding Agency and Grant Number
Corresponding Author	Pochamana Phisalprapa, Associate Professor, Lecturer, MD, PhD, Senior Researcher, Division of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, No. 2 Wanglang Road, Siriraj, Bangkok Noi, Bangkok 10700, Thailand. pochamana.phi@mahidol.ac.th
Key Words	Cost-utility analysis; Diabetes mellitus; Glucagon-like peptide-1 receptor agonists; Metabolic dysfunction-associated steatotic liver disease; Thailand
Core Tip	This cost-utility analysis evaluated semaglutide and liraglutide for adults with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease in Thailand. Using a lifetime Markov model, we found that the incremental cost-effectiveness ratios of both drugs, relative to usual care, exceeded the national willingness-to-pay threshold. Neither drug was therefore cost-effective. Achieving cost-effectiveness would require price reductions exceeding 90%. These findings underscore the urgent need for drug price negotiations to improve treatment access within Thailand’s healthcare system.
Citation	Limwongse S, Chatpattanasiri P, Phuphuang P, Tungthaweethong K, Sutheerayongprasert K, Aunprom-Me W, Kositamongkol C, Phisalprapa P. Cost-utility analysis of glucagon-like peptide-1 receptor agonists for type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease in Thailand. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.123353
PDF	123353-in-press.pdf

Received	2026-05-18 09:31
Peer-Review Started	2026-05-18 09:31
First Decision by Editorial Office Director
Return for Revision	2026-07-05 09:04
Revised	2026-07-17 08:55
Publication Fee Transferred	2026-08-06 02:05
Second Decision by Editor	2026-09-14 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-15 09:27
Articles in Press	2026-09-15 09:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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