Publication Name	World Journal of Clinical Oncology
Manuscript ID	123375
DOI	10.5306/wjco.123375
Country	Thailand

Category	Oncology
Manuscript Type	Minireviews
Article Title	Near-complete clinical response after neoadjuvant therapy in rectal cancer: Decision-making between organ preservation and surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Thanat Tantinam, Kullawat Bhatanaprabhabhan, Boonchai Ngamsirimas, Pawit Sutharat, Rangsima Thiengthiantham, Nataphon Santrakul, Suwan Sanmee, Ekkarin Supatrakul, Punnawat Chandrachamnong and Suradet Buakhrun
Funding Agency and Grant Number
Corresponding Author	Suradet Buakhrun, Consultant, Lecturer, MD, Division of Colorectal Surgery, Department of Surgery, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, 681 Samsen Road, Dusit, Bangkok 10300, Krung Thep Maha Nakhon, Thailand. suradet@nmu.ac.th
Key Words	Rectal neoplasms; Near-complete clinical response; Neoadjuvant therapy; Watch and wait; Organ preservation; Tumor regression; Restaging; Decision-making
Core Tip	Near-complete clinical response after neoadjuvant therapy for rectal cancer is a biologically heterogeneous entity comprising distinct favorable and unfavorable subgroups. Optimal management requires individualized assessment of response trajectory rather than observation duration alone to guide response is biologically heterogeneous-individualize organ-preservation decisions.
Citation	Tantinam T, Bhatanaprabhabhan K, Ngamsirimas B, Sutharat P, Thiengthiantham R, Santrakul N, Sanmee S, Supatrakul E, Chandrachamnong P, Buakhrun S. Near-complete clinical response after neoadjuvant therapy in rectal cancer: Decision-making between organ preservation and surgery. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.123375
PDF	123375-in-press.pdf

Received	2026-05-19 01:58
Peer-Review Started	2026-05-19 01:59
First Decision by Editorial Office Director
Return for Revision	2026-07-07 03:28
Revised	2026-07-10 08:48
Publication Fee Transferred	2026-07-15 07:40
Second Decision by Editor	2026-07-23 07:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 12:28
Articles in Press	2026-07-28 12:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com