Publication Name	World Journal of Hepatology
Manuscript ID	123377
DOI	10.4254/wjh.123377
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Peribiliary and colonic crypt glands in primary sclerosing cholangitis and inflammatory bowel disease pathogenesis: New research perspectives
Manuscript Source	Invited Manuscript
All Author List	Vasiliy Ivanovich Reshetnyak, Alexandra Andreevna Reshetnyak and Igor Veniaminovich Maev
Funding Agency and Grant Number
Corresponding Author	Vasiliy Ivanovich Reshetnyak, Full Professor, MD, PhD, Department of Propaedeutics of Internal Diseases and Gastroenterology, Russian University of Medicine, No. 20 Delegatskaya Street, Moscow 127473, Russia. vasiliy.reshetnyak@yandex.ru
Key Words	Primary sclerosing cholangitis; Inflammatory bowel disease; Peribiliary glands; Glands of colon crypts; Mucins of the bile ducts; Mucins of the colon mucosa; Fucosyltransferase 2
Core Tip	This review presents a novel hypothesis explaining the pathogenesis of primary sclerosing cholangitis (PSC), focusing on the key role of peribiliary glands (PBGs) and colonic crypt glands as a common morphofunctional structure linking pathology of bile ducts and colon. The hypothesis proposes that simultaneous structural and functional impairment of these mucin-producing glands may trigger PSC development. The unifying mechanism, which links PSC and inflammatory bowel disease (IBD) through dysfunction PBGs and colonic crypt glands, probably closely related to mutations in the FUT2 gene affecting fucosylation of protective mucins in bile ducts and colonic mucosa. This hypothesis explains key clinical features of PSC: (1) Selective involvement of extrahepatic and large intrahepatic bile ducts; (2) Formation of characteristic concentric strictures; (3) Strong association between PSC in IBD; (4) Sparing of small intralobular and interlobular bile ducts; and (5) Increased risk of cholangiocellular carcinoma and colorectal cancer. The proposed mechanism provides a comprehensive framework for understanding PSC pathogenesis and identifies potential therapeutic targets.
Citation	Reshetnyak VI, Reshetnyak AA, Maev IV. Peribiliary and colonic crypt glands in primary sclerosing cholangitis and inflammatory bowel disease pathogenesis: New research perspectives. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.123377
PDF	123377-in-press.pdf

Received	2026-05-18 07:42
Peer-Review Started	2026-05-18 07:42
First Decision by Editorial Office Director	2026-06-05 06:04
Return for Revision	2026-06-05 07:06
Revised	2026-06-08 08:45
Publication Fee Transferred
Second Decision by Editor	2026-07-17 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-17 06:57
Articles in Press	2026-07-17 06:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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