Publication Name	World Journal of Diabetes
Manuscript ID	123389
DOI	10.4239/wjd.123389
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Lin Lu, Fang Yu, Hai-Feng Zhou, Ping Hu and Sheng-Lian Gan
Funding Agency and Grant Number
Corresponding Author	Sheng-Lian Gan, Chief Physician, Department of Endocrinology and Metabolism, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 388 Renmin East Road, Changde 415003, Hunan Province, China. ganshenglian03@126.com
Key Words	Comorbid osteoporosis; Diabetes mellitus; Bone metabolic markers; Risk determinants; Parathyroid hormone
Core Tip	Type 2 diabetes (T2DM) is associated with impaired bone quality and an increased risk of fractures. However, assessment based solely on bone density has important limitations. In this retrospective study, patients with T2DM and osteoporosis (OP) exhibited higher serum parathyroid hormone (PTH) and β-C-terminal telopeptide of type I collagen levels than those without OP, suggesting altered bone metabolism. Notably, PTH concentrations in the OP group were more than double those in the non-OP group and were accompanied by evidence of reduced skeletal responsiveness to PTH. Multivariate analysis further identified older age and elevated PTH levels as independent risk factors for OP comorbidity. These findings suggest that routine assessment of PTH and β-C-terminal telopeptide of type I collagen, combined with clinical evaluation, may facilitate the earlier identification of high-risk T2DM patients, thereby enabling early intervention before the occurrence of fragility fractures.
Citation	Lu HL, Yu F, Zhou HF, Hu P, Gan SL. Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.123389
PDF	123389-in-press.pdf

Received	2026-05-22 10:58
Peer-Review Started	2026-05-31 23:57
First Decision by Editorial Office Director
Return for Revision	2026-07-01 04:00
Revised	2026-07-07 14:15
Publication Fee Transferred	2026-07-24 09:08
Second Decision by Editor	2026-07-31 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-31 09:40
Articles in Press	2026-07-31 09:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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