Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123400
DOI	10.4251/wjgo.123400
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Prognostic impact of post-chemoradiotherapy muscle quality in non-elderly adults with esophageal squamous cell carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Ling Xiao, Yu-Hang Yang, Shi-Chuan Zhang and Jia-Hua Lyu
Funding Agency and Grant Number
Corresponding Author	Jia-Hua Lyu, Associate Chief Physician, PhD, Senior Researcher, Department of Radiation Oncology, Sichuan Cancer Hospital, No. 55 Section 4, Renmin South Road, Chengdu 610041, Sichuan Province, China. winlttljh@163.com
Key Words	Esophageal squamous cell carcinoma; Chemoradiotherapy; Skeletal muscle density; Muscle quality; Prognosis
Core Tip	This study enrolled 255 esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy to explore the prognostic role of post-treatment skeletal muscle density (post-SMD). We innovatively identified a nonlinear correlation between age and post-SMD, with 64 years as the optimal cut-off inflection point. Post-SMD exhibited an age-dependent prognostic modifying effect: Reduced post-SMD independently predicted inferior survival exclusively in patients aged < 64 years, while no significant prognostic correlation was observed in elderly patients ( ≥ 64 years). A tailored prognostic model incorporating post-SMD was established for young ESCC patients, which presented favorable discrimination, calibration, and net clinical benefit.
Citation	Xiao L, Yang YH, Zhang SC, Lyu JH. Prognostic impact of post-chemoradiotherapy muscle quality in non-elderly adults with esophageal squamous cell carcinoma. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123400
PDF	123400-in-press.pdf

Received	2026-05-18 08:10
Peer-Review Started	2026-05-18 08:10
First Decision by Editorial Office Director	2026-05-29 03:19
Return for Revision	2026-05-29 03:19
Revised	2026-06-08 18:05
Publication Fee Transferred	2026-06-15 03:19
Second Decision by Editor	2026-07-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 08:25
Articles in Press	2026-07-02 08:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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