Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123408
DOI	10.4251/wjgo.123408
Country	Malaysia

Category	Oncology
Manuscript Type	Opinion Review
Article Title	Tumor-treating fields in gastrointestinal cancers: Mechanisms, clinical evidence, and emerging precision therapy
Manuscript Source	Invited Manuscript
All Author List	Chern E Oon and Bilgin Keserci
Funding Agency and Grant Number	Funding Agency Grant Number JRX Global Sdn. Bhd No. R504-LR-GAL007-0000002762-J157
Corresponding Author	Chern E Oon, Associate Professor, Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Gelugor, Penang 11800, Malaysia. chern.oon@usm.my
Key Words	Tumor-treating fields; Gastrointestinal oncology; Pancreatic cancer; Electric field therapy; Precision oncology
Core Tip	Tumor treating fields are emerging as a novel therapeutic platform in gastrointestinal oncology, linking electric-field physics with tumor biology and patient-specific anatomy. This review highlights pancreatic cancer as the first clinically validated gastrointestinal proof point while critically examining earlier evidence in hepatocellular, gastric, biliary, and colorectal cancers. We propose that tumor treating fields should be viewed not simply as a uniform device exposure but as a patient-specific biophysical prescription. Future progress will depend on integrating computational field modeling, biological susceptibility, real-world treatment adherence, and adaptive planning to optimize effective intratumoral field exposure over time.
Citation	Oon CE, Keserci B. Tumor-treating fields in gastrointestinal cancers: Mechanisms, clinical evidence, and emerging precision therapy. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123408
PDF	123408-in-press.pdf

Received	2026-05-21 06:50
Peer-Review Started	2026-05-21 06:50
First Decision by Editorial Office Director
Return for Revision	2026-07-07 02:52
Revised	2026-07-08 04:58
Publication Fee Transferred
Second Decision by Editor	2026-08-05 03:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:48
Articles in Press	2026-08-05 10:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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