Publication Name	World Journal of Translational Medicine
Manuscript ID	123433
DOI	10.5528/wjtm.123433
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Risk factors for pathological upgrading pre- and post-endoscopic resection of colorectal adenoma: A retrospective study
Manuscript Source	Invited Manuscript
All Author List	Xu-Lin Zheng, Tao Chen, Yang Yu, Neng Wang, Biao Jiang, Yao Yao, Yun-Fei Zhao, Xin-Xin Yu and Chun-Lin Su
Funding Agency and Grant Number	Funding Agency Grant Number the Joint Growth Program for Early Gastrointestinal Cancer Physicians of China, Beijing Huaxia Cancer Prevention and Research Institute Grant No. GTCZ-2024-09
Corresponding Author	Chun-Lin Su, Department of Gastroenterology, Gastrointestinal Endoscopy Center, Suining Central Hospital, No.127 Desheng West Road, Chuanshan District, Suining 629000, Sichuan Province, China. 13408251310@163.com
Key Words	Colorectal adenoma; Colorectal cancer; Pathological upgrading; Endoscopic resection; Risk factor; Retrospective study
Core Tip	Colorectal adenomas (CRAs) are the predominant precancerous lesions of colorectal cancer. Assessing their pathological upgrading risk is critical for early diagnosis and intervention. In this retrospective study, pathological upgrading incidence was significantly higher in adenomas with a diameter > 20 mm than in those ≤ 20 mm. Adenoma diameter was an independent influencing factor for the pathological upgrading of CRAs. CRAs with a diameter > 20 mm are more susceptible to pathological upgrading and carry an elevated risk of undetected high-grade dysplasia or early carcinoma missed by preoperative biopsy. Early and complete endoscopic resection is recommended to prevent progression to colorectal cancer. These findings will enhance clinicians’ diagnostic capabilities and assist in formulating appropriate treatment strategies for CRAs.
Citation	Zheng XL, Chen T, Yu Y, Wang N, Jiang B, Yao Y, Zhao YF, Yu XX, Su CL. Risk factors for pathological upgrading pre- and post-endoscopic resection of colorectal adenoma: A retrospective study. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.123433
PDF	123433-in-press.pdf

Received	2026-05-19 07:40
Peer-Review Started	2026-05-19 07:40
First Decision by Editorial Office Director
Return for Revision	2026-06-17 14:19
Revised	2026-06-27 05:52
Publication Fee Transferred
Second Decision by Editor	2026-07-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 08:17
Articles in Press	2026-07-02 08:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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