Publication Name	World Journal of Diabetes
Manuscript ID	123444
DOI	10.4239/wjd.123444
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Dynamic SERCA regulation and early metabolic dysfunction in young adults with high waist-to-height ratio
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Peng Zhou
Funding Agency and Grant Number
Corresponding Author	Zhi-Peng Zhou, Department of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Rd, Shangjie, Minhou, Fuzhou, Fujian, Fuzhou 350122, --- Select One ---, China. zhouzhipengl@163.com
Key Words	Waist-to-height ratio; Endoplasmic reticulum stress; SERCA; Insulin resistance; Young adults
Core Tip	This commentary extends the findings of Casillas et al. It discusses the biphasic regulation of SERCA as a key determinant of disease progression. It emphasizes the unrecognized metabolic risk in young adults with elevated waist-to-height ratio. It also highlights the cross-disease implications of endoplasmic reticulum stress and JNK activation. These perspectives provide important insights for early risk stratification and mechanism-based interventions.
Citation	Zhou ZP. Letter to the Editor: Dynamic SERCA regulation and early metabolic dysfunction in young adults with high waist-to-height ratio. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.123444
PDF	123444-in-press.pdf

Received	2026-05-19 01:50
Peer-Review Started	2026-05-19 07:40
First Decision by Editorial Office Director
Return for Revision	2026-06-23 02:26
Revised	2026-07-01 13:43
Publication Fee Transferred
Second Decision by Editor	2026-07-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-14 08:08
Articles in Press	2026-07-14 08:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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